FertileThoughts.com - Infertility, adoption, pregnancy and parenting discussions
Mthfr and pai!! Please help!!!

Thanks Thanks:  0
Likes Likes:  0
Dislikes Dislikes:  0
Results 1 to 4 of 4
  1. #1
    lila
    has no status.
    Registered User

    Join Date
    Jun 2009
    Posts
    393
    Post Thanks / Like

    Mthfr and pai!! Please help!!!

    Hello, I have recently been diagnosed with having MTHFR Homozygous C677t mutation and PAI hetero. I have had two miscarriages both from IVF and I was on baby aspirin during both and Folgard for my second pregnancy. I did a couple of RPL tests after my first loss and they found the MTHFR and went to a hematologist after my second one b/c re said no other tests were necessary. The Hematologist did a complete work up and we found the PAI. I am kind of bitter with my re

    Anyway, I am wondering if there is anyone else who has this combination and what treatment you are doing. I want to make sure I am on the right path.

    Oh yeah, any information on the PAI will be greatly appreaciated as well!

    Thank you so much!!!


  2. Advertisement


  3. #2
    sdeut
    has no status.
    Registered User
    sdeut's Avatar
    Join Date
    Aug 2008
    Location
    illinois
    Posts
    2,972
    Post Thanks / Like
    I see a reproductive immunologist and have elavated PAI - 1, MTHFR (but only hetero for the A mutation), and Factor 13 (also a blood clotting issue). I am on BA, Matnx (like folgard) and 40 mg of lovenox.
    Me 33 DH 33
    Highest FSH 17
    2 chemical pg
    Zachary B 4/22/08 D 6/24/08 (due to SMA)
    IVF #1 w/PGD - ectopic
    IVF #2 - m/c 9 weeks

    IVF #3 - BFP - Twins are here


  4. #3
    SWOhoney
    has no status.
    Registered User
    SWOhoney's Avatar
    Join Date
    Oct 2008
    Posts
    632
    Post Thanks / Like
    your protocol should include Lovenox, Metanx and BA. What did your hemotologist recomend?
    heterozygous MTHFR
    RPL
    and male factor
    2 previous mcs in my early 20s
    IVF #1 Aug 2008, BFP, twins, lost one at 6 weeks and the second at 7 weeks.
    IVF #2 Jan 2009 BFN
    FET#1 Apr 2009 BFP! DD Born 1/8/2010
    FET#2 Aug 2011 BFN
    FET #3 Jan 2012 BFN
    New clinic
    IUI #1 Sept 2012 BFN
    IUI #2 Feb 2013 BFP - Chemical
    IUI #3 Apr 2013 BFN
    IVF #3 June 2013


  5. #4
    lila
    has no status.
    Registered User

    Join Date
    Jun 2009
    Posts
    393
    Post Thanks / Like
    Thanks for your responses! My protocol is BA, Folgard, and Lovenox. I just went to RE today and they added the Lovenox. I am hoping that this will work for me. Have any of you had success with this protocol?


Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
DISCLAIMER: Fertile Thoughts allows advertisers to publish information about their services. Fertile Thoughts does not provide medical advice or endorse any particular service or approach to treating infertility. We encourage people to learn as much as possible about the range of options available before committing to any one. We also encourage users to share their thoughts on all fertility options on our forums.

Forum Stats

  • Forum Members: 97,616
  • Total Threads: 352,308
  • Total Posts: 4,534,780
There are 215 users currently browsing forums.

Advertisement

Visit Our Partner Sites: Fertility Treatments