FertileThoughts.com - Infertility, adoption, pregnancy and parenting discussions
Has anyone heard of this as a reason for abnormal embryos?

Thanks Thanks:  0
Likes Likes:  0
Dislikes Dislikes:  0
Results 1 to 8 of 8
  1. #1
    DrAndrea
    has no status.
    Registered User

    Join Date
    May 2009
    Location
    NY
    Posts
    30
    Post Thanks / Like

    Has anyone heard of this as a reason for abnormal embryos?

    I had 8 of my 9 embryos come back as abnormal (three were trisomies and 5 were complex abnormals). I went for a second opinion from another doctor. This doctor said that he thinks the previous RE triggered me too early and the embryos didn't have time to properly go thru meiosis. Hence, the eggs were immature. When they triggered me, I only had one 18 and one 19. He said they should have waited, but figured they didn't because my estrogen was slightly increased.

    Does anyone buy this explanation?
    Me: 31 (NK cells, MFTHR defect, blood clotting issues)
    DH: 38 (translocation on 1 and 16; borderline DNA fragmentation)




    7/30/09 BFP on HPT!!!! (transferred 4 expanding blasts)
    7/31/09 (7dp5dt) beta is 38!!!!
    8/3/09 (10dp5dt) beta is 205!!!
    EDD: April 11, 2010
    We are having a girl!!!!


  2. Advertisement


  3. #2
    lw962
    this TTC crap has not been a joy ride!!!
    Registered User

    Join Date
    Oct 2007
    Location
    Miami, FL
    Posts
    2,615
    Post Thanks / Like
    My Mood
    Happy
    Dr- I was always told that if a follie is immature, it will absolutely not fertilize. Even with icsi. So being that ur follies fertilized, I would suspect that they were mature. So I do not buy ur re's explaination as the embryologist is the 1 that explained this to me. If I were u I would direct any of my follie or embryo quality questions 2 the embryologist as they are educated in this arena.


  4. #3
    mrsbadgerwi
    has no status.
    Registered User

    Join Date
    Jan 2008
    Location
    Wisconsin
    Posts
    1
    Post Thanks / Like
    Andrea - which lab did you use for PGD?


  5. #4
    DrAndrea
    has no status.
    Registered User

    Join Date
    May 2009
    Location
    NY
    Posts
    30
    Post Thanks / Like
    Reprogenetics...

    But it has been many months since I originally posted this message. I did much more testing after the BFN. I found my husband had a balanced translocation. I got treated for blood clotting and autoimmune stuff (steroids, lovenox, intralipids). Then I did IVF a second time without PGD with a new doctor. I put four embryos back and got pregnant with a healthy baby girl. I am now 26 weeks pregnant. Good things are possible!
    Me: 31 (NK cells, MFTHR defect, blood clotting issues)
    DH: 38 (translocation on 1 and 16; borderline DNA fragmentation)




    7/30/09 BFP on HPT!!!! (transferred 4 expanding blasts)
    7/31/09 (7dp5dt) beta is 38!!!!
    8/3/09 (10dp5dt) beta is 205!!!
    EDD: April 11, 2010
    We are having a girl!!!!


  6. #5
    MrsEshaw
    MrsEshaw
    has no status.
    Edit
    Guest
    Andrea,
    Congrats to you and your husband!
    Your story gives me hope! I'm on my 9th day of stims, and have a balanced translocation. We found out after our son was born with unbalanced chromosomes.

    =)


  7. #6
    DrAndrea
    has no status.
    Registered User

    Join Date
    May 2009
    Location
    NY
    Posts
    30
    Post Thanks / Like
    Thanks! It seems like when it comes to a BT that it is just a numbers game. Just put back a lot of embies to increase your odds of success. I am now 30 weeks pregnant and every doctor says that things look perfect! She does have the same BT my DH has but there is not much we can do about that.
    Me: 31 (NK cells, MFTHR defect, blood clotting issues)
    DH: 38 (translocation on 1 and 16; borderline DNA fragmentation)




    7/30/09 BFP on HPT!!!! (transferred 4 expanding blasts)
    7/31/09 (7dp5dt) beta is 38!!!!
    8/3/09 (10dp5dt) beta is 205!!!
    EDD: April 11, 2010
    We are having a girl!!!!


  8. #7
    MrsEshaw
    MrsEshaw
    has no status.
    Edit
    Guest
    It is just a numbers game!
    Luckily I'm fairly young & have no underlying fertility issues. DS was my first pregnancy & we learned of my balanced translocation when he was diagnosed w/cancer at 4mos old. Technically I have a deletion-insertion. Part of my 13th chrom is stuck onto my 10th. So noah got my 13th that was missing a region...and not the 10th with that region of 13 stuck on it which would make him balanced.

    It sucks that my unbalanced pregnancies are viable.

    Don't worry about your daughter, she's be just fine in 20yrs when it's time for her to have children.


  9. #8
    DrAndrea
    has no status.
    Registered User

    Join Date
    May 2009
    Location
    NY
    Posts
    30
    Post Thanks / Like
    Yeah, they said that my DH's translocation segment is so large that the embryo would never implant. So I don't have a history of miscarriages that most people would normally have. I just had a lot of BFNs.
    Me: 31 (NK cells, MFTHR defect, blood clotting issues)
    DH: 38 (translocation on 1 and 16; borderline DNA fragmentation)




    7/30/09 BFP on HPT!!!! (transferred 4 expanding blasts)
    7/31/09 (7dp5dt) beta is 38!!!!
    8/3/09 (10dp5dt) beta is 205!!!
    EDD: April 11, 2010
    We are having a girl!!!!


Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  
DISCLAIMER: Fertile Thoughts allows advertisers to publish information about their services. Fertile Thoughts does not provide medical advice or endorse any particular service or approach to treating infertility. We encourage people to learn as much as possible about the range of options available before committing to any one. We also encourage users to share their thoughts on all fertility options on our forums.

Forum Stats

  • Forum Members: 97,616
  • Total Threads: 352,308
  • Total Posts: 4,534,780
There are 223 users currently browsing forums.

Advertisement

Visit Our Partner Sites: Fertility Treatments