MTHFR Info needed!

[mszidloski]

I just had my second miscarriage after a DE cycle.

My first miscarriage was with my OE and it was automatically assumed my eggs were no good.

I moved onto DE and the same exact thing happened.

I had my OB run an RPL panel and they found I had 2 copies of the same mutation C667t of MTHFR.

If anyone has any info that would be great. The nurse at my REs office made it out like this is no big deal, probably not the cause of my miscarriages and if I want I can add extra folic acid and do Lovenox.

I would have liked some more support and information from them so that's why I am reaching out here.

There has to be a reason for my miscarriages.

Thanks!

[TTCyears]

I had 5 pg losses (RPL) and there was no one reason ... there were many possibilities. I read a study that correlates embryonic MTFHR (dependant on the DW/DE and DH) and gestational carrier (GC) MTFHR with mc. I gathered it's mostly with the embryo itself (DE&DH) or in combo with GC, moreso than the GC alone. That said, folic supplement is pretty typical. I am compound heterozygous MTFHR. For my successful cycle, I took Folgard (like I had for many years of BFNs and mcs); so more importantly DH took LOTS of vits to maximize his contribution (DH's with C667T are more highly correlated to RPL than DW/DE) and I had my uterus reshaped (which 3 REs missed, but the 4th one DX'd). Missing our angels...

[Holly TH]

M,

I am so sorry for your losses. Because you are homozygous for the MTHFR polymorphism (the most severe form of the mutation), you have a very limited ability to break down synthetic folic acid to its active form, L-methylfolate. This puts you at risk for folate deficiency related pregnancy complications. You might want to ask your doctor about L-methylfolate. I work with NeevoDHA, a prenatal specifically indicated for women with the MTHFR polymorphism. It contains active L-methylfolate as an alternative to synthetic folic acid (which you do not properly metabolize). L-methylfolate is 7 times more bioavailable than folic acid. It increases blood folate levels and decreases homocysteine levels more effectively than folic acid. It is something very simple and safe you can try to be sure that folate deficiency is not your issue. As I am sure you know, adequate folate status while trying to conceive is vitally important because of its role in DNA synthesis and repair. I hope you are able to find the answers you are looking for. I do believe that it would be a mistake to completely discount homozygous MTHFR as being related to your repeat losses. I hope you and your doctor are able to come up with a plan to ensure a healthy, happy pregnancy in the very near future. Best of luck!

[TTCyears]

Yeah, I was on L-methylfolate up until my insurance chose not to cover it. Even though it didn't correspond to a sticky BFP, it improved my well being ... I recommend it. Despite my misgivings, I took Folgard b/c it was easier (RE was familiar with it and insurance covered it), but I will be starting L-methylfolate again soon.