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  1. #1
    jax
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    Recurrent Blighted Ovum

    I'm just wondering why?? I'm 99% sure I have another one. This will make 3 total, 2 in the last 6 mo. My initial diagnosis was an ovulation dysfunction. We did ivf in July of '03 and conceived twins-one being viable/carried full term, one a blighted ovum. I didn't think much of it b/c a vanishing twin is quite common, I'm told. Well, I had a spontaneous pregnancy in March, which ended in a blighted ovum. We were so elated that I could get pg naturally and tried to look at our loss as optimistically as possible. I chalked it up to bad luck. Well, we were getting ready to do an FET this month and I found out I was pg again. I had an u/s yesterday showing a 5 wk empty sac. I'm 7 wks from my lmp. My OB is trying to keep me optimistic, but I know my body from tracking it for the past 4 years. The only way to make this pregnancy work is for me to have ovulated 3 weeks into my cycle. I just don't work like that. When I have a long cycle, I don't ovulate. The month prior to getting pg, I had a 28 day cycle. The month before that, it was 38 days. I can tell by the way I bleed when I ovulate. It's just one of those things you know. I had my hormone leves checked immediately. My e2 and progesterone were fine (133 and 43 respectively). So, it's not something hormonal. I started on prometrium anyway. I had 4 betas done, which rose normally, but on the low end of normal. They were 118, 203, 461, and 815. They were all taken every 2 days for 6 days. My betas are also too low for a 7 wk pregnancy. They're consistent with a 5 pregrancy. To me, they are not good at all in comparing them with my ivf pregnancy. I guess I knew this wasn't a good pregnancy after the second beta. The whole scenario is EXACTLY like what happened in March. I know it's over and I'm having another beta to confirm what I know. My symptoms have diminished, too. I have another u/s next week just to stick the knife in a little deeper. We didn't have genetic testing done on the blighted ovum in March, but I'm thinking we should probably have it with this one. I'm just trying to figure out why. I couldn't get pg to save my life prior to ivf and now, I can get pg, but can't stay pg. Is it possible we have something else going on even though I carried a pregnancy full term w/ ivf w/ no problems?? I'm going to call my RE after I have this beta done and ask his opinion before we jump into an FET. I have maintained contact with him throughout this pregnancy, as well. We have 15 frozen embryos all of which are rated extremely good. But what if there is something going on with my immune system or who knows and the pregnancy from ivf was a fluke?? Does anybody have any words of wisdom or advice to share? Thanks for reading if you got this far.

    Amy
    Jacob Christopher 4/5/04
    IVF miracle


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  3. #2
    BC-Shelli
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    I'm so sorry....

    I don't have much advice...hopefully the past blighted ovums were just a fluke and it won't happen again. I do think you are on the right track discussing this with your RE though...maybe he can give you some answers before you start another cycle.
    Shelli~ TTC #2 for 10 years until my body gave out...
    Dx: Chronic Endo/Adenomyosis.....Hysterectomy/LSO 3/9/02......Lap/RSO 12/9/04
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  4. #3
    MarieOz
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    2 of my losses were BO, from what I can understand BO's can indicate 2 possible problems. Immune Issues for you (check out the Immune Issues BB - the ladies over there are very knowledgeable) or issues with your DH's sperm... Or it could just be bad luck. I personally believe we have sperm issues (DQ I think it's called), but was never dx'd. I'm sorry you have suffered another loss, it's just heartbreaking to lose a pregnancy. ((HUGS))
    Noels
    #1 (ttc 7yrs, IUI #5) - 'M' 5 yo
    #2 (ttc 2yrs, IUI #12) - 'W' 2 yo
    3 precious angels to m/c - Aug 99 - July 03 - Nov 03
    and 'D' - our nephew - forever our boy. went back to bm Jan 2004
    "Stop trying to compete and compare, and people will respect you"


  5. #4
    mvp
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    I agree with MarieOz. If I were you I'd get an immune panel done and add a Thrombiphilia panel. I also had 2 pregnancies similiar to yours. My first one I had rising betas, but at 6 weeks there was no baby or sac. The second (a FET) I had a normal start with a h/b at 6 w and then at 10w there was a sac but no baby. I have MTHFR which is an inherited thrombiphilia that can cause elevated homocysteine levels and clotting . Also, I am going to get some more immune testing done as I am not sure that my body isn't attacking the baby.

    There is one more possibility. Do you have a tilted uterus? Oftentimes the baby isn't detected until later because it is harder to see with a tilted uterus. I've heard of quite a few cases of misdiagnosed blighted ovums.


  6. #5
    jax
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    Quote Originally Posted by mvp
    Do you have a tilted uterus? Oftentimes the baby isn't detected until later because it is harder to see with a tilted uterus. I've heard of quite a few cases of misdiagnosed blighted ovums.

    Yeah, I do have a tilted uterus. That would absolutely wonderful if that ended up being the case. However, I'm prepared for nothing to be there on the next u/s. I almost feel kind of crampy. I'm going for another beta today to see if there is a decline going on.

    I have spoken w/ my RE's nurse and will be going in for another consult prior to attempting the FETs. Dh and I are going to insist on having the recurrent m/c b/w done. We don't want to even think about the FETs until we can rule out things. Hopefully, this is really dumb luck or my body is just incapable of a good ovulation. Since this was the issue before, I'm hoping it's still the issue now. Thank you all for your advice. I really appreciate it.

    Amy
    Jacob Christopher 4/5/04
    IVF miracle


  7. #6
    Lauren2005
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    Yes, please have your DQ Alpha numbers checked (both you and DH). If one of his two numbers is 0201, he would have a 50% chance of creating a blighted ovum. Obviously both of his numbers aren't 0201, because you've already had a baby (congratulations! ) But I wouldn't be surprised if one number was 0201. Hope that helps.

    Lauren

    endo, PCOS, multiple early losses, currently benched from ttc for immune issues tx

    NOTE: please see my next post for important additional step: DQ Beta testing.
    Last edited by Lauren2005; 09-30-2005 at 12:42 PM.


  8. #7
    jax
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    Quote Originally Posted by Lauren2005
    Yes, please have your DQ Alpha numbers checked (both you and DH). If one of his two numbers is 0201, he would have a 50% chance of creating a blighted ovum. Obviously both of his numbers aren't 0201, because you've already had a baby (congratulations! ) But I wouldn't be surprised if one number was 0201. Hope that helps.

    Lauren

    endo, PCOS, multiple early losses, currently benched from ttc for immune issues tx
    Lauren,

    Thanks for the info!! I was trying to do some research on the DQ Alpha. So, if his sperm w/ the 0201 has fertilized my egg, my body will attack it, right? Can I take something so my body won't attack it or is the embryo worthless?? It's so hard to understand all of this sometimes!!
    Jacob Christopher 4/5/04
    IVF miracle


  9. #8
    Lauren2005
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    Hi Jax,

    Sorry, in my previous post, I said to check the DQ Alpha numbers to look for DQ Alpha 0201, which is correct, but I indicated that this would be all the information you'd need. There is another step. If DH's DQ Alpha number is 0201, he needs a DQ Beta test. THAT test result is the one that relates to blighted ovums.

    What you described is what the DQ Alpha numbers are ordinarily all about. If you share a number with your DH, it's possible (but not always the case) that your body will think the growing embryo is actually cancer and kill it. Both DQ Alpha numbers by DH are used to create the placenta. The mom-to-be's DQ Alpha numbers are NOT used to create the placenta. So you can see how a matching number (or two) might cause trouble early in the pg. The actual baby receives one number from each parent.

    The problem with blighted ovum is different. There is more than one reason for a blighted ovum, so this may not be the answer at all! However, repeated blighted ovums are rare and a red flag for the following:

    If your DH has at least one DQ Alpha 0201, there is a 2% chance that he has at least one DQ Beta 0201. (BTW, it's clear that your DH doesn't have TWO copies of DQ Beta 0201, because he has already had children.) If only one DQ Beta number is 0201, he has a 50% chance of producing an embryo that is 0201. DQ Beta 0201 embryos always become blighted ovum. The answer is "to put back more embryos to see if you can produce an embryo that is not DQ 0201," according to the reproductive immunology book I'm reading.

    Now, this part is NOT your DH: If both of a man's DQ Alpha numbers are 0201, and both of his DQ Beta numbers are 0201, then according to the book the only answer is donor sperm because he can only produce blighted ova.

    So, like I said, this isn't the only reason for blighted ovum, but it's worth looking into. The DQ Alpha test is simple, and I'm sure the DQ Beta test is just as simple if needed. It might be a red herring, but worth considering. Hope that helps!

    Lauren


  10. #9
    jax
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    Lauren,

    Thank you so much. I'm going to print this b/c I have to read it over and over for it to sink in. I have one more question. Can PGD pick up these embryos should this be the case? You would think that some of the embryos we have frozen would be good. Gosh I hope this isn't the case, but like you said, something just isn't right for this to have happened 3 times. Thanks again for the info. I'll probably be over on the immune issues board (can't think of its official name) sooner than later.

    Amy

    ETA: By the way, what book are you reading??
    Last edited by jax; 09-30-2005 at 01:46 PM.
    Jacob Christopher 4/5/04
    IVF miracle


  11. #10
    ohene_ba
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    hi

    I'm new to all this and just found this site today while searching online for some answers to my problems. I have had three miscarriages in the last 7 months and two were diagnosed blighted ovums. I've never had kids before. I live in Africa as a missionary, so I can't just make an appointment and go see a specialist - there aren't any! What is the first step to trying to find a cause for recurrent blighted ovums? Any help would be appreciated! Thnx.


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