Updates for the week of 9/7 ~*~*

[Ferret Mommy]

Please come in and let us know how you are doing!

[Ferret Mommy]

I am in the 2WW with about a week left! Staying busy with my classes and work. Have done 2 tests, 2 papers and working on my 3rd paper.. its a busy week!!

[DMS721]

*child mention*

My little guy is 2 months old tomorrow. Time is going by way too fast. I have to return back to work tomorrow, and that is breaking my heart. I'm still not even sure what grade I'll be teaching this year, as with all the budget cuts, my grade level has changed 4 times in the past week.

Dawn

[Ferret Mommy]

Dawn... 2 months already?? I am so sorry you have to go back so soon! I know that when I was out, I took all the FMLA I could after the DR let me go back! Its so not easy!! Many hugs! I hope you have a good first day back.. and what do you mean you dont know? Dont you have to get lessons in order? KUP!!

[Ferret Mommy]

Mel- Great job on the weight loss.. that will help you over all. However, with PCOS, you could have it and not be overweight. I was DX when I was around 15 and I was skinny as a pole. I had issues with ttc#1, but did do it naturally after 6 months of clomid and on my second month of being off of it. This round, after some strange cycles I asked for Metformin and it has made me lose weight AND return my cycles and ovulate!!

I do not know of a way to make you actually Ovulate naturally. To ovulate, you have to have all you hormones working properly and with PCOS you have a tendency to produce more androgen hormone....

What causes polycystic ovary syndrome (PCOS)?

The cause of PCOS is unknown. Most researchers think that more than one factor could play a role in developing PCOS. Genes are thought to be one factor. Women with PCOS tend to have a mother or sister with PCOS. Researchers also think insulin could be linked to PCOS. Insulin is a hormone that controls the change of sugar, starches, and other food into energy for the body to use or store. For many women with PCOS, their bodies have problems using insulin so that too much insulin is in the body. Excess insulin appears to increase production of androgen. This hormone is made in fat cells, the ovaries, and the adrenal gland. Levels of androgen that are higher than normal can lead to acne, excessive hair growth, weight gain, and problems with ovulation.

[melpart]

Ferret Mommy- what would cause sore breasts, exhaustion, constipation, and taste bud changing. For example cooking and eating corn (which i love) is gross and smells and tastes like burnt corn? People usually says its all in my head but how can i imagine all of this when i actually experiencing all of this?

[Ferret Mommy]

Where are you in your cycle Mel? Have you tested?

[AshRS]

Hey guys,

Had a CD16 ultrasound yesterday and still no growth. I will see the RE on Friday...I will mention Femara. I am a little nervous about it though...I know some of you have used it and its been fine, but it just makes me uncomfortable that the research isn't out on it...I don't know if he'll even prescribe it. If we do the injectables we will also be doing IUI because the injectables are so expensive...

[Ferret Mommy]

Ash.. I know when I was on clomid I od really late.. Maybe you will still, but just later? I sure hope so!!

Femara from Clinical Pharmacology
For the treatment of infertility† in women due to anovulation, irregular ovulation, or luteal phase defects, including women with polycystic ovary syndrome (PCOS):
NOTE: Ensure that patients are not pregnant prior to initiating letrozole. While the outcomes of pregnancies in one cohort study demonstrate a similar rate of miscarriage and ectopic pregnancy in women who took letrozole versus other drugs for ovarian stimulation [31753], the manufacturer of letrozole urges physicians to ensure that letrozole is not used in women who may become or are pregnant; birth defects have been reported in the children of women who were receiving letrozole during pregnancy.
Oral dosage:
Adult premenopausal females: Limited studies indicate that 2.5 mg, 5 mg, or 7.5 mg PO once daily for 5 days, typically given on days 3—7 of the menstrual cycle, may be effective; in a study comparing 2.5 mg letrozole (n=34) to 5 mg letrozole (n=38) PO daily for 5 days, pregnancy rates per cycle were significantly higher in patients treated with the higher dosage (26% vs. 6%, p<0.05).[32940] Alternatively, a single dose of letrozole 20 mg PO on day 3 of the menstrual cycle has been shown to be as effective as 2.5 mg PO once daily for 5 days in a nonrandomized study [32939], although more data are needed before a single dose can be recommended. In general, ovulation and pregnancy rates are comparable to those with clomiphene (pregnancy rates per cycle of 9—27% for letrozole vs. 5.6—26% for clomiphene).[32937][32938][32941] Efficacy has also been demonstrated in patients with PCOS; ovulation occurred in 66% (65/99) of letrozole cycles vs. 75% (71/95) of clomiphene cycles, with pregnancy rates per cycle of 9% vs. 7%, respectively.[32942] In addition, successful pregnancies have occurred when letrozole is administered to patients who do not respond to clomiphene (lack of ovulation or insufficient endometrial thickness). In 30 patients that were treated with clomiphene 100—150 mg/day for 6—24 cycles, the administration of letrozole 2.5 mg (n=4) or 5 mg PO (n=26) PO once daily during menstrual cycle days 3—7 was associated with an ovulation rate of 90% and a pregnancy rate of 26%; pregnancy occurred during cycles 2—5 of letrozole therapy.[32943]

[AshRS]

the manufacturer of letrozole urges physicians to ensure that letrozole is not used in women who may become or are pregnant

thats the part that makes me nervous!