how do all of you settle your nerves and do

ocean view · 07-21-2009, 02:38 PM

the jump to become pregant. I am 40 and thinking bout doing IVF with icsi but met with the gentics counselor and the % seem very high for an issue. We don't have any thing wrong with us were just a normal family trying to have baby but the risk seem high. Have you all used you own eggs and how do you get past the nerves of the chromosone disorders? My ob said one of her partners in her practice is pregant at 44 but she would have had a abortion if the baby was abnormal.The baby is normal so there is no worries there but I know that is not for me and I just would like to know how you'll all settle your nerves and take the leap? Do you just hold your breath until you get past the screening.

linden · 07-22-2009, 02:57 PM

ocean view: If you are going to do IVF to get pregnant, I suggest doing pre-implantation genetic diagnosis (PGD) on your embryos prior to transfer. The embryologists can screen the embryos for aneuploidy and you can have only "normal" embryos transferred to your uterus. I am currently 25 weeks pregnant after a successful cycle of IVF w/ ICSI and PGD. I started TTC at age 28 and began IF treatment at age 32. At age 33, with the help of IF treatments, I became pregnant twice and lost both pregnancies due to chromosomal abnormalities. That's when I decided to move on to IVF and to use PGD to screen the embryos for abnormalities, rather than go through more miscarriages and D&C (and emotional hell!).

Check out the www.sbivf.com website. That's the clinic I went to and they have info online about PGD.

Good luck!!!

ocean view · 07-22-2009, 05:40 PM

Can you tell me what the cost of PGD is? thanks for your reply

linden · 07-23-2009, 06:13 AM

It's expensive. It was about 5,000 dollars. We will be paying it off for a while, but it has given us so much peace of mind, esp. since our first two pregnancies ended in miscarriage due to aneuploidy at age 33, which I thought was relatively young in the infertility world, but I guess I have "old eggs". Even without a history of recurrent miscarriage, I'm pretty sure that my IVF clinic recommends PGD for patients over 37 years of age.

it's-jp · 09-19-2009, 06:32 PM

I know this thread is a few months old but, I still wanted to put in my two cents.

My first pregnancy happened when I was 39 and was a missed miscarriage discovered at 10 weeks. My second pregnancy came at 41. At our nuchal scan, their was lots of fluid on his neck...we had a cvs and he was a trisomy 18 baby. We miscarried 2 weeks later.

After two miscarriages, I told my RE I didn't want to try IVF with anything but embryos that had a fighting chance if there was anything we could do to help that. So, we did pgd with our first IVF cycle. They retrieved 18 eggs...10 fertilized...9 made it to day three...and one...yes, one..made it through pdg. Every other embryo had multiple trisomies.

Now I am 9w4d pregnant with that one good emby. :-) For us, it was almost exactly $5000 for the pgd alone but I have to say it was worth every penny considering the odds we really had when we looked at the embryo report.

jodiann808 · 09-21-2009, 05:57 PM

You should know, though, that PGD is only 90% accurate. There's a 10% chance that the one cell from the embryo that they analyzed was abnormal while the remaining cells were normal. This would cause them to label a good embryo as abnormal. Vice versa is also a possibility - the one cell they analyze could be normal while all the other cells are abnormal. They could then transfer this back thinking it was a good embryo.

We debated whether or not to do PGD. Our genetic counselor told us, though, that at least 50% of any woman's eggs (regardless of age) are likely to be bad. This number gets higher as a woman ages. When she told us this, we decided it would be worth the extra money to do the PGD and increase our odds. You will also want to have a high number of fertilized embryos to start with before doing PGD. The PGD process will weed out a lot of embryos, so will letting them grow to 5 day blasts. If you don't have a large number of embryos to start with, you may not have anything left to transfer on day 5.

07-21-2009, 02:38 PM	#1 (permalink)
ocean view 200-299 post 4 of hearts Join Date: Sep 2006 Posts: 216	how do all of you settle your nerves and do the jump to become pregant. I am 40 and thinking bout doing IVF with icsi but met with the gentics counselor and the % seem very high for an issue. We don't have any thing wrong with us were just a normal family trying to have baby but the risk seem high. Have you all used you own eggs and how do you get past the nerves of the chromosone disorders? My ob said one of her partners in her practice is pregant at 44 but she would have had a abortion if the baby was abnormal.The baby is normal so there is no worries there but I know that is not for me and I just would like to know how you'll all settle your nerves and take the leap? Do you just hold your breath until you get past the screening.

07-22-2009, 02:57 PM	#2 (permalink)
linden 800-899 post 10 of hearts Join Date: Jan 2008 Location: Summit, NJ Posts: 804	preg. mentioned, recurrent m/c mentioned ocean view: If you are going to do IVF to get pregnant, I suggest doing pre-implantation genetic diagnosis (PGD) on your embryos prior to transfer. The embryologists can screen the embryos for aneuploidy and you can have only "normal" embryos transferred to your uterus. I am currently 25 weeks pregnant after a successful cycle of IVF w/ ICSI and PGD. I started TTC at age 28 and began IF treatment at age 32. At age 33, with the help of IF treatments, I became pregnant twice and lost both pregnancies due to chromosomal abnormalities. That's when I decided to move on to IVF and to use PGD to screen the embryos for abnormalities, rather than go through more miscarriages and D&C (and emotional hell!). Check out the www.sbivf.com website. That's the clinic I went to and they have info online about PGD. Good luck!!!

09-19-2009, 06:32 PM	#5 (permalink)
it's-jp 0-99 post 2 of hearts Join Date: Aug 2009 Location: PA Posts: 86	I know this thread is a few months old but, I still wanted to put in my two cents. My first pregnancy happened when I was 39 and was a missed miscarriage discovered at 10 weeks. My second pregnancy came at 41. At our nuchal scan, their was lots of fluid on his neck...we had a cvs and he was a trisomy 18 baby. We miscarried 2 weeks later. After two miscarriages, I told my RE I didn't want to try IVF with anything but embryos that had a fighting chance if there was anything we could do to help that. So, we did pgd with our first IVF cycle. They retrieved 18 eggs...10 fertilized...9 made it to day three...and one...yes, one..made it through pdg. Every other embryo had multiple trisomies. Now I am 9w4d pregnant with that one good emby. :-) For us, it was almost exactly $5000 for the pgd alone but I have to say it was worth every penny considering the odds we really had when we looked at the embryo report. __________________ Janice Me (42) DH (33) TTC since 2002 Natural preg 04/06 mis @ 10w IUI#1 - 10/06 BFN IUI#2 - 12/06 BFN IUI #3 - 02/07 BFN Started adoption process 08/07 Natural preg 04/08 mis @ 12w (trisomy 18) Failed adoption 11/08 IVF#1 - 07/09 transferred 1 embie - BFP!! woot! 7w0d u/s - hb = 120 8w1d u/s - hb = 152 9w0d u/s - hb = 164 EDD: April 20, 2010

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07-22-2009, 05:40 PM	#3 (permalink)
ocean view 200-299 post 4 of hearts Join Date: Sep 2006 Posts: 216	Can you tell me what the cost of PGD is? thanks for your reply

07-23-2009, 06:13 AM	#4 (permalink)
linden 800-899 post 10 of hearts Join Date: Jan 2008 Location: Summit, NJ Posts: 804	It's expensive. It was about 5,000 dollars. We will be paying it off for a while, but it has given us so much peace of mind, esp. since our first two pregnancies ended in miscarriage due to aneuploidy at age 33, which I thought was relatively young in the infertility world, but I guess I have "old eggs". Even without a history of recurrent miscarriage, I'm pretty sure that my IVF clinic recommends PGD for patients over 37 years of age.

09-21-2009, 05:57 PM	#6 (permalink)
jodiann808 0-99 post 2 of hearts Join Date: Aug 2009 Location: San Jose, CA Posts: 16	You should know, though, that PGD is only 90% accurate. There's a 10% chance that the one cell from the embryo that they analyzed was abnormal while the remaining cells were normal. This would cause them to label a good embryo as abnormal. Vice versa is also a possibility - the one cell they analyze could be normal while all the other cells are abnormal. They could then transfer this back thinking it was a good embryo. We debated whether or not to do PGD. Our genetic counselor told us, though, that at least 50% of any woman's eggs (regardless of age) are likely to be bad. This number gets higher as a woman ages. When she told us this, we decided it would be worth the extra money to do the PGD and increase our odds. You will also want to have a high number of fertilized embryos to start with before doing PGD. The PGD process will weed out a lot of embryos, so will letting them grow to 5 day blasts. If you don't have a large number of embryos to start with, you may not have anything left to transfer on day 5.