Yes it can happen. Here is part of our story from my blog.
http://infertilereflections.blogspot.com/
Since one of Joe’s ex-wives had a miscarriage while they were married and a girl friend once told him she had an abortion we figured he would pass with flying colors. We were shocked when he didn’t. Azoospermia ~ the complete absence of sperm. None! Nada! Zero! Zip! The Urologist (UR) asked if he’d had a vasectomy; like that’s something he might have forgotten. After that he mentioned that the testosterone replacement that Joe had been taking for a couple of years since he had been diagnosed with very low testosterone; could effect sperm production. I did have some inkling that it could lower his counts, but no idea that it could completely stop it. Besides I thought it was only when testosterone was being abused and the level got too high that it was a problem and Joe’s level was slap dab in the middle range of normal.
The options the UR gave us were for Joe to quit taking the supplements for 3 months and see if that worked or to do a biopsy of his testicles to see if he had any sperm or sperm producing cells. He also suggested an US of his testicles to check for blockages, since Joe’s exam showed no signs of Varicocele. (enlarged veins that can cause lower sperm counts) The US came back clear and after 3 months off the testosterone Joe felt awful because his hormone level was so low and his sperm count was still zero. We were told our only option’s now were for him to have the biopsy and if they found sperm then we could try IVF with ICSI (they inject a single sperm into each harvested egg) or we could use donor sperm. If they found no sperm with the biopsy then without donor sperm neither of us would have a biological child.
We decided that we would try the biopsy and have donor sperm as a backup just in case they didn’t find any.
(Because of other medical issues we had to delay ttc for about a year and this is where the story continues.)
After discussing all our options again, we decided to move ahead and talk to the UR about the biopsy. But we both mentioned that we didn’t really click with the UR he’d seen and that maybe we could find someone else that we liked better. I searched the internet and found Dr Larry Lipshultz . Joe was lucky to get an appointment pretty quickly. After discussing what the first UR had told us and what tests he had preformed, Dr Lipshultz wanted his own SA just in case things had changed in the last year and to insure that his lab couldn’t find a few strays that the other lab had missed. No such luck. I was pretty skeptical when the Dr. suggested that he still thought that the testosterone might be the culprit, but Joe was willing to try almost anything to keep that needle away from his boys. At least he didn’t want to play wait and see for three months again while Joe testosterone plummeted, he suggested a combination of a pill (Nolvadex) that would tell Joe’s body to produce testosterone and a shot (Novarel) that would tell it to produce sperm. One month later Joe was back in the office leaving a deposit, that night they called us with the results. Joe had 9 sperm. I think the guy who called couldn’t figure out why we were so happy. It was enough to try IVF without the biopsy; but even better it meant we had a chance of having our child.
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