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  1. #1
    SandiLI
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    Embryo Grading???

    Hi Guys,

    You would think I would be an expert at knowing all this info, but I'm not. I'm confused about the grading. I know there are stages of A,B and C. What does AA, BB, etc. mean. I was reading my old records from my RE with the cycle I got pg with my son and I had 2 4AA and 1 5BB put in on day 5. This recent cycle I had 1 5cell grade B and 1 7cell grade B put in on day 3. Does the AA, BB mean when it goes to blast???
    Sandi 38 yrs old, ovarian failure at age 16
    DE IVF #1 6/01, neg
    DE IVF #2 10/01, son
    DFET #3 10/03, neg
    DE IVF #4, 3/31/05 neg
    DFET #5, 11/10/05 It's Twins! Boy and a Girl, born 7/12/06


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  3. #2
    stephanie72
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    The double letter grading happens when the embryo has gone to blast, from what I've been told. The grading starts at A (being the best) and goes down from there. The letters refer to the zona (shell) and the actual embryo inside. Not sure which one comes first in terms of letter order though. So if you have AA, that means both the zona and the actual embryo are excellent, perfect quality.


  4. #3
    SandiLI
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    Thanks your info. helped a great deal.
    Sandi 38 yrs old, ovarian failure at age 16
    DE IVF #1 6/01, neg
    DE IVF #2 10/01, son
    DFET #3 10/03, neg
    DE IVF #4, 3/31/05 neg
    DFET #5, 11/10/05 It's Twins! Boy and a Girl, born 7/12/06


  5. #4
    HopefulInTn
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    found this info on grading on internet

    The following is an approximate timetable of events for IVF:

    Day 0 Egg retrieval
    Sperm collection and preparation
    Insemination
    Day 1 Check eggs for fertilization (the presence of two pronuclei or PN's)
    Day 2 Embryos at the 4-cell or more stage of development
    Day 3 Embryos at the 8-cell or more stage of development
    Day 4 Embryos at the compacted morula (16-32 cell) stage
    Day 5 Embryos at the blastocyst stage of development

    You can ask the Lab Director (or physician) to give you progress reports on the development of your embryos. Critical points in development are (1) fertilization, (2) 4 to 8 cell stage and (3) morula to blastocyst stage.

    Numeric grading systems for multicell embryos usually have 4 levels:

    Grade 1: even cell division, no fragmentation
    Grade 2: even cell division, small fragmentation
    Grade 3: uneven cell division, moderate fragmentation
    Grade 4: uneven cell division, excessive fragmentation

    Blastocysts are graded differently with a number and two letters.

    The number refers to the degree of expansion of the blastocyst (1 is the least expanded, 6 is the most expanded). The first letter (A,B, or C) refers to the quality of the inner cell mass (the part of the blastocyst that is going to be the baby) and the second letter (A, B, or C) refers to the quality of the trophectoderm (the part of the blastocyst that is going to be the placenta).

    Multicell embryos that recieve grade 1 or 2 often develop to the blastocyst stage, those receiving grade 3 or 4 rarely develop to the blastocyst stage. Sometimes the laboratory uses the reversed scale where a grade 4 embryo is equivalent to a grade 1 embryo on the above scale. Check with your lab.

    It is unusual to be allowed to go into the IVF laboratory to view your embryos in person since the lab is a sterile room like an operating room. Special clothes, hats, gloves, shoe covers etc., are required. These are not usually supplied to the patients, just lab personnel. You can, however, ask for a picture of your embryos as many labs document the embryo development with photographs or video images. Ask the Lab Director what the policy is. When you see the picture, ask for an interpretation, embryo stage, grades etc.


  6. #5
    SandiLI
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    Thanks for all the info. it was great. I actually found out the information I needed from the Lab as you mentioned.

    I am currently pregnant with twins. I had three embryos put back and who knows which ones took?!? I had a 6 cell, 8 cell and 1 in a morula stage. It's very exciting.

    Thanks again for all your time in typing a reply to me.
    Sandi 38 yrs old, ovarian failure at age 16
    DE IVF #1 6/01, neg
    DE IVF #2 10/01, son
    DFET #3 10/03, neg
    DE IVF #4, 3/31/05 neg
    DFET #5, 11/10/05 It's Twins! Boy and a Girl, born 7/12/06


  7. #6
    qrychefan
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    I just found this post. Thanks for all of the useful info.
    TTC 3.5+ yrs

    2005: 2 IUI cycles - BFN ; 1 cancelled IUI
    2006: 1st attempt IVF Feb 2006 - BFN ; 2nd attempt IVF May 2006 - BFN ; Final attempt FET Oct 2006 - BFN
    2007+: Going "au naturale". Maybe we'll get fortunate...


  8. #7
    RyansHope
    My chickie's closing in on TWO!!
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    So then the best grade for a blast are AA1 and goes down from there?

    We're doing a 6day transfer on Sunday and only know that of my 33 eggs retrieved, that 27 fertilized.
    The nurse told me today that the lab does not continually check quality as disturbing them would be detrimental to them??


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