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  1. #1
    Aunt2bMomSoon
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    Estrogen level at 7dpo (4dp3dt)

    Hello ladies,

    I had my estrogen level checked today (4dp3dt/7dpo) and it was 450. Last cycle it was 470 at this point and the cycle ended up in BFN.

    I was wondering if any of you have the estrogen level checked after the transfer? If so, what was it? What is the acceptable amount of estrogen? When would the level be considered low enough to require estrogen supplements?

    Lastly, what does estrogen level mean at this point in the cycle? Is it any indicator of whether the implantation will be successful or not?

    Thanks in advance.
    Me (34) DH (34); TTC 2003; PCOS, overweight & IR, low sp vol and slightly low morph
    6 failed IUI (1 Clomid; 4 Bravelle; 1 Gonal-F)
    IVF #1 - M/C 1.28.07 (8w3d) due to subcho bleeding
    IVF #2 - June 07 BFN
    IVF #3 - Dec 07 BFN
    IVF #4 – May 08 - beta 11dp3dt 5.31.08 = 507; beta 17dp3dt = 4326 (IVF/ICSI, co-culture, no bcp, clomid + inj)
    1st u/s 6.9.08 twins. 11w5d u/s lost 1 twin at 8w2d.


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  3. #2
    hilarynjon
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    I had this problem with my IVF. I started my AF on 7DP3DT! I was so upset at my doctors because of all the money we spent and also in my records they had that I needed the HCG boosters in my luteal phase so there isnt a short luteal phase. Because it was IVF they dont do additional boosters because of risk of OHSS. They do however do the Vivelle estrogen patches. I did not have them though. On our FET we have a ton of estrogen suppliments. I am on a natural cycle now and I am 15DPO and no period yet. I did two booster shots and 400mg prometrium. So the boosters do really work to keep your luteal longer.


  4. #3
    Aunt2bMomSoon
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    Hi Hilary ~ good luck with your natural cycle.. no AF is a good sign
    Me (34) DH (34); TTC 2003; PCOS, overweight & IR, low sp vol and slightly low morph
    6 failed IUI (1 Clomid; 4 Bravelle; 1 Gonal-F)
    IVF #1 - M/C 1.28.07 (8w3d) due to subcho bleeding
    IVF #2 - June 07 BFN
    IVF #3 - Dec 07 BFN
    IVF #4 – May 08 - beta 11dp3dt 5.31.08 = 507; beta 17dp3dt = 4326 (IVF/ICSI, co-culture, no bcp, clomid + inj)
    1st u/s 6.9.08 twins. 11w5d u/s lost 1 twin at 8w2d.


  5. #4
    pw2007
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    Why is estrogen needed after transfer? I thought progesterone was all that was needed.

    Thanks.


  6. #5
    Kim_n_Mike
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    Estrogen helps progestrone absorb in the body is what I am told.


  7. #6
    Aunt2bMomSoon
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    pw ~ I am not too sure myself... I thought the estrogen level indicated the quality of the lining and whether it is good enough for implantation..
    Me (34) DH (34); TTC 2003; PCOS, overweight & IR, low sp vol and slightly low morph
    6 failed IUI (1 Clomid; 4 Bravelle; 1 Gonal-F)
    IVF #1 - M/C 1.28.07 (8w3d) due to subcho bleeding
    IVF #2 - June 07 BFN
    IVF #3 - Dec 07 BFN
    IVF #4 – May 08 - beta 11dp3dt 5.31.08 = 507; beta 17dp3dt = 4326 (IVF/ICSI, co-culture, no bcp, clomid + inj)
    1st u/s 6.9.08 twins. 11w5d u/s lost 1 twin at 8w2d.


  8. #7
    Aunt2bMomSoon
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    I surfed the internet and found the below info on webmd.com:

    Estrogen Affects Fertility Window
    A Little Helps; Too Much May Hurt IVF Success

    WebMD Medical News

    Feb. 10, 2003 -- The difference between a healthy pregnancy and an unsuccessful in vitro fertilization (IVF) attempt may be less than few nanograms of estrogen. New research shows even the tiniest variations in a woman's estrogen levels may help explain why up to 70% of healthy embryos fail to implant themselves in the uterus.

    A study in today's online edition of the Proceedings of the National Academy of Sciences suggests that estrogen plays an important role in determining the window of opportunity for an embryo to attach itself to the uterine wall and begin development.

    Although a small amount of estrogen is needed to make the uterus receptive to the embryo, researchers found slightly too much of the hormone can alter the necessary genetic process at the implantation site in the uterus and can drastically shorten the fertility window.

    Women undergoing IVF procedures tend to have high estrogen levels because of the drugs used to stimulate egg production. But a woman's estrogen levels may also be affected in other ways, such as the foods she eats, environmental toxins, or ethnic differences.

    In the study, researchers removed the ovaries of female mice to stop the normal production of estrogen and progesterone, which are needed for successful embryo implantation. They later gave the mice daily injections of progesterone and one low dose of estrogen followed by a second high or low dose after embryo transfer. They found that a single second dose of either 3, 10, or 25 nanograms of estrogen was capable of inducing implantation.

    But while the lowest dose extended the window of opportunity in mice to up to four days, increasing the dose to 10 nanograms shortened it to less than 24 hours.

    "The most exciting aspect of this investigation is that a very narrow range of estrogen levels can alter embryo implantation and gene expression," says researcher Sudhasu K. Dey, PhD, of the Division of Reproductive and Developmental Biology at Vanderbilt University in Nashville, Tenn., in a news release.

    Dey says altering the dose of progesterone didn't seem to have any effect on uterine receptivity.

    Although replicating the results of this study in humans may be difficult, researchers say that the findings suggest that careful regulation of estrogen levels may offer a new way to improve the success of IVF procedures.
    Me (34) DH (34); TTC 2003; PCOS, overweight & IR, low sp vol and slightly low morph
    6 failed IUI (1 Clomid; 4 Bravelle; 1 Gonal-F)
    IVF #1 - M/C 1.28.07 (8w3d) due to subcho bleeding
    IVF #2 - June 07 BFN
    IVF #3 - Dec 07 BFN
    IVF #4 – May 08 - beta 11dp3dt 5.31.08 = 507; beta 17dp3dt = 4326 (IVF/ICSI, co-culture, no bcp, clomid + inj)
    1st u/s 6.9.08 twins. 11w5d u/s lost 1 twin at 8w2d.


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