4g and 5g questions

[BC-tnahope]

x-post

My Ob office just called and the Dr. reviewed my b/w So last time I called Im guessing the nurse was looking at differant b/w or it hadn't been reviewed by the Dr. yet. He wants me on a baby aspirin every day and WHEN (thats what she said, I like that ) I get PG I will need more b/w and possibly heperin. Now these are her words, Im still a little confused and not sure what this means. "The factor 5 came back fine and that is good but the numbers for 4g and 5g are a little off. Baby aspirin will work fine in the begining but we need to make sure your numbers arent changing during PG. "

Anyone know anything about this?

[poohbear]

BC-TNA,
Sounds like you have some answers. You are talking about a thrombophilia?
It sounds like they tested you for PAI-1 4G/5G test. Women with PCOS also can test positive for that mutation. I have one copy but I don't have PCOS. Here's the thing. You can have two copies of a mutation homozygous or one copy heterozygous. Having two copies of one mutation is more serious. There are other various thrombophilias they can test you for. Factor V is one of them. There is also Factor II, Factor XII, B-Fibrinogen, HPA1 a/b(L33P). There is MTHFR Hyperhomocysteinema which inhibits a person's ability to absorb folic acid and theire homocystine levels can rise making a person at risk for clots and cardiovascular issues. I would find out if you have one or two copies of the mutation. Overall it's not just a pregnancy issue, it can be a long-term health issue down the road. Many of us take baby aspirin and go on lovenox which is low molecular weight heparin when pg. Heparin you have to take 2x a day and lovenox is 1x a day. Lovenox is no picnic but obviously worth it if you can maintain a pg. You can look up the tests on the internet although it can make your head spin! Wishing you success!
Stacey

[BC-tnahope]

My head is already spinning. Im hopeing the Dr will explain a little more when I meet with him(although that is not until Nov.) Yes she did mention thrombophilia but said the Factor 5 is fine , just 5g and 4g are off. Im not sure about all the tests...yet so I will list what it says on my order.
ANA
anti-Thrombin III
Lupus anticoagulant
Protein C&S
Leiden Fastor 5
Homocysteine
Prolactin
PAI 1 genotype
Prothrombin Gene mutation
MTHFR 677, 1298
Antigen activity.

Thanks so much for the help Poohbear, you have been a sanity saver

[poohbear]

Your very welcome!
Those are the tests I had. The PAI 1 is the 4G/5G I'm pretty sure. I have that one off too. That's good if only you have one that's off. I had to wait 3 months for my appt. with the hematologist. Can they put you on a cancellation list? If you take the baby aspirin and then get a BFP and do the lovenox which you RE can prescribe you'll be fine. Initially my hematologist told me I could start he lovenox after BFP but my RE is having me do it post O. Every doctor has their own philosophy on it.

[BC-tnahope]

I didnt know I would need to see a hematologist Is it important to get into one? My Ob is the one that has made all the decisions on testing etc. so far.

[poohbear]

You probably don't have to see one. Some of my testing was done my family practice doctor and I had to see rheumatologist and then a hematologist. The hematologist would prescribe lovenox for me if I needed.

[BC-tnahope]

Ok, for now Ill stick with my Ob but I will bring it up when I see my family Dr. next.

[poohbear]

Good luck!

[BC-tnahope]

Thanks, you too!!