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  1. #1
    msshino
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    Positive for ATA (Antithyroid antibodies)

    Hi Ladies,

    I tested positive for antithryroid antibodies. Just my anti thyroglobulin antibodies came back high (110). I have all the symptoms of hypothyroidism but my RE will not treat me since my TSH level is normal (2.09). Does anyone else who has tested for ATA suffer from hypothyroidism symptoms, chronic fatigue, infections, and inflammed thyroid?

    I was wondering if testing for ATA means that something besides my thyroid is causing infertility.

    I can't seem to get pregnant and I was told my eggs were bad by my RE. Could something be attacking my eggs before ovulation? Or could something be killing a fertilized embryo?

    I am on the quest to finding another RE or RI here in Colorado that has more information on this immunology stuff. I think I know more than my RE does.

    Also I just got tested for other autoimmune diseases and sent off more samples to Millenova for NK, AOA and embryotoxicity testing. I hope there will be more clues here.

    Shino


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  3. #2
    jeppy
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    I too have antithyroid antibodies....I just got re-tested today but was dx a year ago. I have totally normal tsh (under 2 and abover 1)....so they are not treating it at this time. I do have a nodule that is benign but now I've bend dx with chronic uticaria (hives). I think there is a connection between the thyroid antibodies and the hives but with the tsh good - they won't treat it.....this is frustrating!

    I hope you get some help and good news from a new RE.
    I too worry that my autoimmune system is crazy and may be attacking things it should not.....


  4. #3
    msshino
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    I hear you. I forced my RE to let me get tested with Millenova for immune testing. However, even if something came up positive they won't treat it. I think in my case IVIG is the treatment for antithyroid antibodies but that's not accepted by my RE. Geesh! I never thought it would be this hard to get treated.

    Are they treating you with something for your hives? Strong anti-histamine or corticosteroids? I too get a lot of skin infections. I get small rashes here and there and easily get ring worm infections. Definitely a sign of a weak immune system. I definitely think there is a connection. Do you have any other REs or RIs in your area that might be more willing to help? I'm searching but many REs in colorado are not for immunotherapy. Where to go from here.

    Shino


  5. #4
    msshino
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    jeppy,

    did they test you for NK activity? Just wondering since you mentioned mild endo. When you have mild endo you tend to have antibodies fighting. Once the endo gets worse, your body doesn't react the same. Just curious.

    Shino


  6. #5
    jeppy
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    Shino -

    I do have endo and I suspect that over the last few years of cycling that it has gotten worse. I have not and will not be testing for NK cells. .... my RE does not believe that this makes a difference and that the treatment does not help. She has treated people who wanted NK treatment without success...only to concieve later on without the treatment.

    Because of this - at this time will not be considering NK testing or treatment. But I am intersted in treating other immune issues - and therefore take Levonex during my cycles. My RE is the best in the state and we work with a specialist in Seattle..where I travel for procedures. I have a great team and I know they will find something that is treatable...hoping and praying

    I am taking Zyrtec. Singulair, and Zantac 2x a day for the hives....we believe it is chronic but praying not -cause if it is immune related then that will continue to put things on hold......


  7. #6
    shel517
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    Hi Shino,
    I know this is an old thread, but I thought I might be able to bump it up and ask some questions/ share some info. I had two PGs in about 6 months, both ended in mc. First was large yolk sac, second blighted ovum. We were assuming it was bad eggs/age related-I am 42, almost 43.
    Well, after the second mc the RE suggested running a RPL panel to make sure we weren't missing anything. I thought he was just doing it to be nice because I was tearing up during the u/s that confirmed pg wasn't viable, and everything would come back normal.
    It turns out that my ATA level was at 700. I am starting a very low dose of sytheroid tomorrow and during my next IVF cycle I'll be doing steroids beginning before retrieval. I don't know much about the whole ATA thing, though the RE did say that in the future I will probably have a full blown hypothyroid. He also said that there have been some studies linking ATA to early mc.
    I'd love to hear any info you have!
    Best,
    Michele


  8. #7
    msshino
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    I am not sure if I had antithyroid antibodies with my IVF cycle, but I did get pregnant. I had a large yolk sac too and they said it was bad eggs. I don't believe that just yet. All my tests comeback just fine except for a high ATA level of 110.
    I believe that my chances at a successful IVF decreased with my dh's sperm which caused the fragmentation. So hang in there. Corticosteroids are the best, Medrol and Dexamethasone is what I used. Also I hear Prednisone is safe during early pregnancy.
    I have been attempting IUI's with donor sperm with no success. I wonder if it's the eggs or if it's just antibodies preventing me from getting pregnant. No one else thinks so but me.
    Good luck

    shino


  9. #8
    msshino
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    Beautifuldey,

    Did you take Medrol, Dexamethasone or Prednisone when you had your successul pregnancy?

    I know there has to be something that I am missing. I get cold and then sometimes I get really hot, almost like a hot flash. Something is wrong. I am going to try switching doctors.

    Shino


  10. #9
    shel517
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    I had pretty severe hot flashes with my first IVF. I was at Target one night and I was pretty sure my legs were on fire.


  11. #10
    msshino
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    I don't think I've had a true hot flash yet but something close. My head feels like it's burning and I can't stop it from happening. I hope it's not hormonal and something with my thyroid.


    Shino


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