Positive APA Blood Result???

SandiLI · 03-10-2005, 10:02 AM

I'm wondering if anyone is familiar with APA (antiphospholipid antibodies). I just got the news that I tested positive to this. Not good!!! I'm in the process of my 4th DE IVF.

I'm told that I was very lucky to have given birth to my DS. APA is a clotting blood factor which is common for causing miscarriages. To help in the prevention of this a baby asprin and injections of heparin, which are blood thinners are given daily.

I'm a little freaked right now. My RE said it has been stated that a lot women who need egg donors are prone to having this APA. He also stated that a lot of people don't test for this. I did 3 prior IVF's with another clinic and I was never tested.

Just was wondering if anyone could shed some light on this topic?

LynnUS · 03-10-2005, 12:23 PM

Hi,
Testing + for APA means you have a clotting disorder which can prevent implantation, so you never even know if you got pg or wreak havoc on a pg at any time if not treated, by causing clotting to occur in the placenta, preventing nourishment from getting to the baby.
THe good news is, tx is pretty simple, ba and a blood thinner like heparin or Lovenox.
What you might want to also test for is the presence of high NK activity as well since a high % of women who have +APA also have killer cells.
I took Lovenox and ba through my successful pg w/DD and am doing so again. It really is not a big deal and obviously is very well worth the injections in the end!

Hope this helps! Best of luck.

Lynn
9yrs ttc#1 "unexplained"
4 angels
Madeleine, 3-1/2 w/IVIg, LIT, Lovenox, ba
dx: uterine NK, hetero MTHFR, dq alpha match
3 yrs ttc#2
4 more angels
currently pg on a natural cycle w/immune meds

Josie1021 · 03-13-2005, 07:08 PM

Sandi - here is a useful link for you. I have come across many women who have had successful pregnancies with this when treated with heparin and aspirin.

http://www.hughes-syndrome.org/

Good luck

Josie

SandiLI · 03-14-2005, 12:17 PM

Thank you both so much for your input and helpful information. I will let you know how I make out.

Thanks again!

03-10-2005, 10:02 AM	#1 (permalink)
SandiLI Registered User Join Date: Feb 2002 Location: Long Island, NY Posts: 371	Positive APA Blood Result??? I'm wondering if anyone is familiar with APA (antiphospholipid antibodies). I just got the news that I tested positive to this. Not good!!! I'm in the process of my 4th DE IVF. I'm told that I was very lucky to have given birth to my DS. APA is a clotting blood factor which is common for causing miscarriages. To help in the prevention of this a baby asprin and injections of heparin, which are blood thinners are given daily. I'm a little freaked right now. My RE said it has been stated that a lot women who need egg donors are prone to having this APA. He also stated that a lot of people don't test for this. I did 3 prior IVF's with another clinic and I was never tested. Just was wondering if anyone could shed some light on this topic? __________________ Sandi 38 yrs old, ovarian failure at age 16 DE IVF #1 6/01, neg DE IVF #2 10/01, son DFET #3 10/03, neg DE IVF #4, 3/31/05 neg DFET #5, 11/10/05 It's Twins! Boy and a Girl, born 7/12/06

03-10-2005, 12:23 PM	#2 (permalink)
LynnUS Registered User Join Date: Jan 2002 Location: Long Grove, IL Posts: 3,445	Hi, Testing + for APA means you have a clotting disorder which can prevent implantation, so you never even know if you got pg or wreak havoc on a pg at any time if not treated, by causing clotting to occur in the placenta, preventing nourishment from getting to the baby. THe good news is, tx is pretty simple, ba and a blood thinner like heparin or Lovenox. What you might want to also test for is the presence of high NK activity as well since a high % of women who have +APA also have killer cells. I took Lovenox and ba through my successful pg w/DD and am doing so again. It really is not a big deal and obviously is very well worth the injections in the end! Hope this helps! Best of luck. Lynn 9yrs ttc#1 "unexplained" 4 angels Madeleine, 3-1/2 w/IVIg, LIT, Lovenox, ba dx: uterine NK, hetero MTHFR, dq alpha match 3 yrs ttc#2 4 more angels currently pg on a natural cycle w/immune meds __________________ JAK, 7/28/05 MAK, 6/25/01

03-14-2005, 12:17 PM	#4 (permalink)
SandiLI Registered User Join Date: Feb 2002 Location: Long Island, NY Posts: 371	Thank you both so much for your input and helpful information. I will let you know how I make out. Thanks again! __________________ Sandi 38 yrs old, ovarian failure at age 16 DE IVF #1 6/01, neg DE IVF #2 10/01, son DFET #3 10/03, neg DE IVF #4, 3/31/05 neg DFET #5, 11/10/05 It's Twins! Boy and a Girl, born 7/12/06

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03-13-2005, 07:08 PM	#3 (permalink)
Josie1021 Registered User Join Date: Mar 2004 Posts: 161	Sandi - here is a useful link for you. I have come across many women who have had successful pregnancies with this when treated with heparin and aspirin. http://www.hughes-syndrome.org/ Good luck Josie