Anyone have a Prothrombin Gene Mutation??

[Monique <3]

Hi all! I was diagnosed with hetero prothrombin gene mutation after suffering 2 m/c. 1st m/c in nov 2010, 2nd m/c in aug 2011. After my 2nd m/c my OB sent me to a RE and he ran a series of tests - which lead to my dx. We are now talking about treatments to help prevent another m/c and lovenox is the recomended treatment plan. I am a little bit of a hypochondriac and when I hear the risks of "what could happen" I get totally freaked out. Of course i want to do it if it can help me have a baby. I have had no problem getting pg both times. My 1 st m/c happened at 6 weeks and I did not have a d&c and no tissue was tested. My 2nd m/c happened at 10 weeks and baby had genetic abnormalities (turner syndrome), this obviously could have been a major factor in my m/c but since we do not know what happened the 1st time, it is questionable. I have read some of your posts and heard some of your success stories. I am just looking for some hope and guidance. Sometimes you feel like youbare the only one going through this so it is nice to hear success stories of others in a similar situation. Thanks, and sorry for rambling on!

[Erin83]

Welcome Monique!!!! I'm sorry you have to join us here with the same problems. I'm sorry you had to find out by having 2 m/c's. That really sucks. I'm glad to hear you don't have any problems getting pg. I don't have any success stories for you, as I have only had 1 m/c and tons of problems getting pg. I've been on Lovenox for the last 4 1/2 yrs. Its not too bad. I don't really feel the needle or the medicine anymore. I haven't had any effects from it. I'm sorry I have no other info or experences to share with you. If you have any questions, feel free to jump in and ask!! Good luck to you!!

Erin

[malea00]

@Monique <3
Well I wanted to let you know that after 5 m/c's over a 10 year span (not ttc) I had one stick. With my history of m/c's my OB sent me to a specialist... I was dx with MTHFR, Factor 2 Prothrombin Gene Mutation, PAI-1 and Lupus Anti-coagulant all are clotting disorders. I was immediately put on baby asprin, Lovenox and a high dose folic acid (MTHFR) prenatal.
Anyhow between that, my weight @ 235, all day every day morning sickness, gestational diabetes, preclampsia and my liver shutting down I wound up in the hospital for @ 32 weeks to get my DS lungs developed quicker with steroids. He was finally taken via c-section @ 33 weeks gestation weighing in at a rough and tumble 5 pounds even, thanks to the gestational diabetes . He spent 3 weeks in the NICU where he figured out how to eat, breath and thrive all on his own. He is now 22 months old and my diabetes, preclampsia and liver issues were taken care of by him being born, ha, the little turkey was killing me. I'm thinking about doing it again soon because he is so worth it.

[Erin83]

OMGoodness Malea. Sounds like you have had your trials, but sounds like you have a miracle boy!!!! I think thats wonderful!! I'm sorry you had such a terrible pg, but I'm sure you would do it again in a heartbeat!!! I'm glad your lil one is here and is happy and healthy now!!!! Best of luck to you on trying again!!!

Erin

[angelini]

Hi ladies - I hope this thread isn't too old to post on again, but I hope someone can help me. My GP ordered blood tests since my sister has a disorder, and found out I have 'Prothrombin G20210A Mutation' - Heterozygous, like she does. He said I shouldn't have any problems TTC but gave me a referral, but I can't see the hematologist until 22nd March.

I've been TTC for 8 months now and no luck - I am ovulating, so I wonder if I should start on aspirin to help with implantation? I have an appointment with a different GP on Monday (I only saw the one who ordered the BTs twice and he's on holiday for the entire month of January!) and I'm going to ask her if she can fax a referral through to the hematologist so I can get in sooner ... bleugh, I am just feeling lost and don't know where to turn.

[Erin83]

Hello welcome!!!! Its never too old to post on here, there will always be someone to reply back. I'm so sorry you have been diagnosed with this disorder, but know you're not alone. Everyone so often someone else will post on here that they are newly diagonsed.
I wouldn't put yourself on any kind of blood thinner until you see the hemo. Let them do it because a lot of that stuff is prescibed based on your weight. So just to be sure its safe for you...you should probably wait it out. I'm glad you're Oing, thats great!! Hopfully your doc will put you on something and that will help with implantation. My cousin has this same thing and she got pg and is still pg, so it is possible. Good luck to you!!! Please keep us posted!!! I hope you can get into a hemo sooner, that blows having to wait, but thats the way it goes I guess. Good luck!!

Erin

[angelini]

Thanks for the response, Erin. Hopefully I will be able to talk to the GP on Monday so he can fax my referral to the hemo and get me in sooner ... we'll see!

Anybody else have any ideas if this could be keeping me from getting pregnant or if it is mostly a m/c issue? Neither is very appealing, to be honest!

[faithdream]

Hi Everyone! My sweet boy is 10 months tomorrow. Maybe you saw my other posts- it has been a long road- but all worth it. I have a 5 year old, then after 4 m/c I got prego with my boy. I have prothombin gene mutation. I also have symptoms of PCOS. I was ovulating but I realize now how once I was on clomid it helped "the perfect egg" drop and with the right timing we were able to start progestrone and lovenox right away. Before clomid I was ovulating but late in my cycle and the egg quality goes down. If anyone is looking for advise I would say #1 find a fertility doctor you trust and question every option- it helps to have a plan.