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  1. #1
    stephisa
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    Very low Papp A- blood test results?

    Anyone with very low Papp A blood test results? I had the nuchal translucency u/s yesterday and got the results of a normal nt scan (2.0), a normal HCG level, but extremely low Papp A (.2) . It apparently could mean.....possible genetic problem with the baby, possible placental problems in the 2nd and third trimester, possible hypertension issues for me, or it could be a result of the fertility treatment (FET) we had to conceive. I am 33 years old and this is my second pregnancy. Other than horrible morning sickness, I've had no problems with either pregnancy. Is anyone else out there experiencing anything like this??? Steph


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  3. #2
    lalalalala
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    Mine was .41 which is the lowest 10 percent. The nuchal fold was 1.0 which is normal and HCG normal too.

    I also am worried but the geneticist didn't have much to say about it. I have my first appt. with peri (I'm pregnant with twins) on Tuesday and plan to get detailed info on what a low PAPP-A level could mean.

    I have a subchorionic hemorrhage and I wonder if the two could be connected. I'll share what I find out next week. Let me know if you get further insight as well. Good luck.


  4. #3
    Twins_Squared
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    Steph...no advice here, just wanted to lend some support. Will you be doing more frequent u/s or having any addt'l follow-up with a Peri/geneticist?


  5. #4
    stephisa
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    Thank you for the replies. Apparently, I will be having more blood tests and u/s around the 16 week mark. I will also be going to see an OB whose area of research is low Papp A. I live in Canada, so our health system is a bit different to the US.

    Lalala...I've been trying to research Papp A and almost all of the info is terribly scientific and I can't understand it!

    Please let me know what you find out and I'll do the same!


  6. #5
    Blondie8
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    I had a low Papp A result and after consultation with my Peri (I'm probably in the same city as you!) have firmly decided that it doesn't mean alot. There is a correlation between women with first trimester Papp A's and some the complications that you mentioned, particularly low birth weight, increased prematurity and hypertension in the Mother. Thusfar there has not been a causal link identified.

    The other treatment per se is increased monitoring of b/p and growth and development. I am already seeing various Docs every week or 2 for other stuff so I'm well covered in that department. Given my other health issues I'm already at increased chance of the same things as the Papp-A shows and my chances don't increase as a result of this finding therefore, I'm not too concerned. I'm currently 23 wks and all growth/development and bp has been completely normal. Oh yeah, it's standard protocol to send you to the AMA Clinic at BCWH with a + Papp-A.

    Feel free to PM me if I can be of any help.
    “Children don’t belong to us. They are litle strangers who arrive in our lives and give us the pleasure and duty of caring for them–but we don’t own them. We help them become who they are.” Gloria Steinem


  7. #6
    stephisa
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    Blondie,

    I noticed you tried to private msg me, but it didn't go through...could you please send it again? Thanks! I am glad to hear your pregnancy is going well!

    Stephanie


  8. #7
    seas
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    I also was told at the nt scan that I had low papp-a mom levels. Mine were 0.29 My doctor told me that it just means they will do an u/s every four weeks to watch the growth after 26 weeks. I also have to have my AFP checked at 16 weeks. I can't help but worry. I just pray that it doesn't turn out to be like everything you read. I think the worst thing I did was google it. I'm sorry I did that. My OB really didn't seem too concerned. She said there is no way to tell what will come of it. That it's just a warning sign. Good luck to you!


  9. #8
    somestang
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    CVS test as a result of low Papp a

    Hi-
    I just received the news that I am at higher risk for Trisomy 13 and 18 (genetic disorders). They came to this conclusion because I had a very low Papp a protein and a very low free beta protein. My ultrasound was normal. They are sending my husband and I to a genetic counslor tomorrow morning and scheduling me for a CVS procedure. This procedure will tell for sure if my baby will have a genetic disorder. I am so scared. I have a healthy 7 month old baby boy and feel blessed. But I can't help to think what will happen with this pregnancy. Anyone have the CVS test done??
    Jaime-Lyn


  10. #9
    lalalalala
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    I didn't have the CVS but did have a low PAPP-A result (bottom 10 percent). Wishing you luck with the CVS and hoping it comes back fine. Did they tell you how low the hcg/beta and PAPP-A were and what your overall risk was? That's a good sign the nuchal fold was normal in the u/s which I what I'm assuming they checked.

    Don't worry!


  11. #10
    stephisa
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    I've been to see a specialist and have had 2 u/s now since my low papp-a results (.29). My nuchal scan was normal as was hcg. I was offered an amnio, but not the CVS. For us, we had IVF so I didn't want to risk miscarrying a possibly healthy baby even though there is a risk of downs (1/76). My 18 week u/s is tomorrow and they said they can tell a lot by that u/s. Will update if I k now anymore.

    Jamie-Lyn- good luck with your CVS.


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