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Genetic Issues This board is open to all members who face a genetic issue whether they be trying to conceive, during pregnancy or parenting. Topics discussed on this board will include: preimplantation gentic diagnosis, prenatal testing (chorionic villus sampling a

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Old 11-13-2009, 10:05 AM   #1 (permalink)
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Join Date: Oct 2009
Location: los angeles
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sri624 Level 1
37yrs and TTC after D&C/prenatal testing

Hello everyone..I am so grateful for this site. The support I have received here since my D&C 4 weeks ago has been wonderful. I am 37, and anxious to TTC once I get my period...IUI/Clomid. We went in for our prenatal testing at 12 weeks and heard the worst news...the baby was severly deformed, and would not survive...(fluid on the back of the head/spine, organs developing outside the abdominal wall, and the umbilical cord deformed. We were told this was a chromosonal issue...most likely Trisomy 18. My RE and the specialst who performed the prenatal testing told me that in most cases when the baby is this sick, a woman would have a miscarriage. "Nature is not perfect" is what he said....urging us to end the pregnancy which we did. Both of these specialist tell us to "try" again, and that this was a "fluke." My question to you is...is it really a fluke. I am 37 and afraid that this will happen again. Because of my age, can I expect to have another miscarriage due to a chromosonal problem? The stats look so grim on many of the websites that I visit about women over 35. Is my chance for a "good egg" just wishful thinking?

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Old 11-14-2009, 12:48 PM   #2 (permalink)
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cpgal Level 1
Chromosomal issues are very common - whatever your age is and it might not be a bad egg but a bad sperm. So don't shoulder all of the responsiblity here. I had a missed miscarriage at 10 weeks (and then Dand C) the testing showed a male with triploidy. The doctor told us that the chances of this particular thing reoccuring is less than 1%. I did a lot of medical journal reading and found that this is true and that there is no link between it and maternal age. In fact, most of these hiccups should have miscarried earlier, or not implanted, etc. But, some do.

I would bet dollars to donuts that this will hold true for you.

I am 36, and honestly, my numbers are really really good but my DH's morphology is terrible. I am more worried about his sperm than my eggs right now. There are differing opionions as to whether morhpology can cause miscarriages and potential chromosomal issues.

If all of your hormone levels are good then your eggs are probably okay. The next time you get pregnant it will probably be fine. Miscarriages are so common that it takes you to have more than two to be an issue. That is depressing. Because as you know, it is devastating and you always mourn the loss.
__________________
Me 36, DH 37.
1st on our own missed miscarriage at 10 weeks (triploidy)
Male factor infertility (morphology)
IVF #1 1/2010
Beta #1 11dp 3dt 320
Beta #2 18dp 3dt 5796
1st U/S 6w - 2 sacs, 1 heartbeat
2nd U/S 6w6d -120 133
3rd U/S 8w3d -169 measuring 8w3d
174 measuring 8w6d
TWINS!
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Old 11-16-2009, 03:56 PM   #3 (permalink)
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sri624 Level 1
Thank you cpgal....your reply is very much appreciated. I hope that this does not happen again. We are going to try again. I am sorry for your loss. I know how difficult this can be. The information on chromosonal issues you provided is very helpful....and you are right miscarriages are so common. I pray everything goes well the next time around. Just waiting on my period now....it has been 4 1/2 weeks. I am anxious to try again.....IUI/Clomid. I wish you the best on your next cycle...I know you mentioned trying 2 cycles on your own, and then IVF. Thanks again for replying.
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Old 11-22-2009, 08:40 AM   #4 (permalink)
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taylohalo Level 1
sri624 & cpgal,

I want to give you both big hugs. Sri, I want to keep a close eye on your thread as I would like to get more information on genetic testing.

I too am 36 and have had 2 miscarriages this year alone. I also had an ectopic in 06. My last 2 miscarriages have been the same: at 9-1/2 weeks, we discover no heartbeat. The docs say 70% of the time it's something wrong with the baby. I am more concerned with the fact that I've had 2 m/cs with the exact same results at the exact same time. Are both of these flukes? I don't think so.

Like you, sri...I'm ready to try again because I am not giving up. My issue is that the docs tell me that I must have 3 missed abortions in order to be considered for genetic testing. I was horrified due to my age thinking I may be running out of time. TTCing at this age can be so frustrating but my hopes are high.
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Old 11-23-2009, 12:18 PM   #5 (permalink)
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sri624 Level 1
Hi Taylohalo,

I am sorry for your losses...hugs to you as well. I have heard that even 2 miscarriages is considered to be "common." I can't imagine but that is what I have read. I also read that even women who have had 2 mc go on to have healthy babies. I see what you mean about the mc being at 9 1/2 weeks, no hb, both times...but from what my doctor tells me, it can happen. Did you have any testing done to the tissue after your mc....to test for chromosonal abnormalities? I am told that most mc are the result of this. Unfortunately, my doc did not test for this....he said it was a "fluke." as well and wants us to try again. I think it is ridiculous that we have to have 3 mc in order for genetic testing to be done...so heartwrenching. I do know that with IVF, they can test the embryos for chromosonal abnormalities before they put them inside of you...the IVF and the PGD testing is very expensive from what I understand..and the testing is not covered by insurance. If I have another miscarriage, I really do want to consider going this route....somehow...someway. But for now, we are going to do the IUI/Clomid and hope that there are no problems. I am terrified but I really want to start ttc asap. My AF came last week, and now I am on Clomid....IUIs should be sometime next week. I just want to be pg again....and of course there is that TIME factor. Keep us posted on what you decide. I will do the same.
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Old 11-23-2009, 12:46 PM   #6 (permalink)
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taylohalo Level 1
My doctor told me the fetus was too small to be tested and that he would send my DH and I to be tested. At our age, I also think it ridiculous to wait for any type of testing. I've contacted my RE in hopes of some information. Thanks for the info. Babydust to you.
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