Has anyone heard of this as a reason for abnormal embryos?

DrAndrea · 05-09-2009, 05:52 AM

I had 8 of my 9 embryos come back as abnormal (three were trisomies and 5 were complex abnormals). I went for a second opinion from another doctor. This doctor said that he thinks the previous RE triggered me too early and the embryos didn't have time to properly go thru meiosis. Hence, the eggs were immature. When they triggered me, I only had one 18 and one 19. He said they should have waited, but figured they didn't because my estrogen was slightly increased.

Does anyone buy this explanation?

lw962 · 05-12-2009, 09:31 PM

Dr- I was always told that if a follie is immature, it will absolutely not fertilize. Even with icsi. So being that ur follies fertilized, I would suspect that they were mature. So I do not buy ur re's explaination as the embryologist is the 1 that explained this to me. If I were u I would direct any of my follie or embryo quality questions 2 the embryologist as they are educated in this arena.

mrsbadgerwi · 12-31-2009, 07:09 AM

Andrea - which lab did you use for PGD?

DrAndrea · 12-31-2009, 07:37 AM

Reprogenetics...

But it has been many months since I originally posted this message. I did much more testing after the BFN. I found my husband had a balanced translocation. I got treated for blood clotting and autoimmune stuff (steroids, lovenox, intralipids). Then I did IVF a second time without PGD with a new doctor. I put four embryos back and got pregnant with a healthy baby girl. I am now 26 weeks pregnant. Good things are possible!

MrsEshaw · 01-30-2010, 03:14 PM

Andrea,
Congrats to you and your husband!
Your story gives me hope! I'm on my 9th day of stims, and have a balanced translocation. We found out after our son was born with unbalanced chromosomes.

=)

DrAndrea · 01-30-2010, 03:21 PM

Thanks! It seems like when it comes to a BT that it is just a numbers game. Just put back a lot of embies to increase your odds of success. I am now 30 weeks pregnant and every doctor says that things look perfect! She does have the same BT my DH has but there is not much we can do about that.

MrsEshaw · 01-30-2010, 03:35 PM

It is just a numbers game!
Luckily I'm fairly young & have no underlying fertility issues. DS was my first pregnancy & we learned of my balanced translocation when he was diagnosed w/cancer at 4mos old. Technically I have a deletion-insertion. Part of my 13th chrom is stuck onto my 10th. So noah got my 13th that was missing a region...and not the 10th with that region of 13 stuck on it which would make him balanced.

It sucks that my unbalanced pregnancies are viable.

Don't worry about your daughter, she's be just fine in 20yrs when it's time for her to have children.

DrAndrea · 01-30-2010, 03:38 PM

Yeah, they said that my DH's translocation segment is so large that the embryo would never implant. So I don't have a history of miscarriages that most people would normally have. I just had a lot of BFNs.

05-09-2009, 05:52 AM	#1 (permalink)
DrAndrea 0-99 post 2 of hearts Join Date: May 2009 Location: NY Posts: 41	Has anyone heard of this as a reason for abnormal embryos? I had 8 of my 9 embryos come back as abnormal (three were trisomies and 5 were complex abnormals). I went for a second opinion from another doctor. This doctor said that he thinks the previous RE triggered me too early and the embryos didn't have time to properly go thru meiosis. Hence, the eggs were immature. When they triggered me, I only had one 18 and one 19. He said they should have waited, but figured they didn't because my estrogen was slightly increased. Does anyone buy this explanation? __________________ Me: 31 (NK cells, MFTHR defect, blood clotting issues) DH: 38 (translocation on 1 and 16; borderline DNA fragmentation) 7/30/09 BFP on HPT!!!! (transferred 4 expanding blasts) 7/31/09 (7dp5dt) beta is 38!!!! 8/3/09 (10dp5dt) beta is 205!!! EDD: April 11, 2010 We are having a girl!!!!

12-31-2009, 07:37 AM	#4 (permalink)
DrAndrea 0-99 post 2 of hearts Join Date: May 2009 Location: NY Posts: 41	Reprogenetics... But it has been many months since I originally posted this message. I did much more testing after the BFN. I found my husband had a balanced translocation. I got treated for blood clotting and autoimmune stuff (steroids, lovenox, intralipids). Then I did IVF a second time without PGD with a new doctor. I put four embryos back and got pregnant with a healthy baby girl. I am now 26 weeks pregnant. Good things are possible! __________________ Me: 31 (NK cells, MFTHR defect, blood clotting issues) DH: 38 (translocation on 1 and 16; borderline DNA fragmentation) 7/30/09 BFP on HPT!!!! (transferred 4 expanding blasts) 7/31/09 (7dp5dt) beta is 38!!!! 8/3/09 (10dp5dt) beta is 205!!! EDD: April 11, 2010 We are having a girl!!!!

01-30-2010, 03:21 PM	#6 (permalink)
DrAndrea 0-99 post 2 of hearts Join Date: May 2009 Location: NY Posts: 41	Thanks! It seems like when it comes to a BT that it is just a numbers game. Just put back a lot of embies to increase your odds of success. I am now 30 weeks pregnant and every doctor says that things look perfect! She does have the same BT my DH has but there is not much we can do about that. __________________ Me: 31 (NK cells, MFTHR defect, blood clotting issues) DH: 38 (translocation on 1 and 16; borderline DNA fragmentation) 7/30/09 BFP on HPT!!!! (transferred 4 expanding blasts) 7/31/09 (7dp5dt) beta is 38!!!! 8/3/09 (10dp5dt) beta is 205!!! EDD: April 11, 2010 We are having a girl!!!!

01-30-2010, 03:38 PM	#8 (permalink)
DrAndrea 0-99 post 2 of hearts Join Date: May 2009 Location: NY Posts: 41	Yeah, they said that my DH's translocation segment is so large that the embryo would never implant. So I don't have a history of miscarriages that most people would normally have. I just had a lot of BFNs. __________________ Me: 31 (NK cells, MFTHR defect, blood clotting issues) DH: 38 (translocation on 1 and 16; borderline DNA fragmentation) 7/30/09 BFP on HPT!!!! (transferred 4 expanding blasts) 7/31/09 (7dp5dt) beta is 38!!!! 8/3/09 (10dp5dt) beta is 205!!! EDD: April 11, 2010 We are having a girl!!!!

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05-12-2009, 09:31 PM	#2 (permalink)
lw962 1000-4999 post queen of hearts Join Date: Oct 2007 Location: Miami, FL Posts: 4,328	Dr- I was always told that if a follie is immature, it will absolutely not fertilize. Even with icsi. So being that ur follies fertilized, I would suspect that they were mature. So I do not buy ur re's explaination as the embryologist is the 1 that explained this to me. If I were u I would direct any of my follie or embryo quality questions 2 the embryologist as they are educated in this arena.

12-31-2009, 07:09 AM	#3 (permalink)
mrsbadgerwi 0-99 post 2 of hearts Join Date: Jan 2008 Location: Wisconsin Posts: 1	Andrea - which lab did you use for PGD?

01-30-2010, 03:14 PM	#5 (permalink)
MrsEshaw 0-99 post 2 of hearts Join Date: Jan 2009 Location: Cambridge, MA Posts: 75	Andrea, Congrats to you and your husband! Your story gives me hope! I'm on my 9th day of stims, and have a balanced translocation. We found out after our son was born with unbalanced chromosomes. =)

01-30-2010, 03:35 PM	#7 (permalink)
MrsEshaw 0-99 post 2 of hearts Join Date: Jan 2009 Location: Cambridge, MA Posts: 75	It is just a numbers game! Luckily I'm fairly young & have no underlying fertility issues. DS was my first pregnancy & we learned of my balanced translocation when he was diagnosed w/cancer at 4mos old. Technically I have a deletion-insertion. Part of my 13th chrom is stuck onto my 10th. So noah got my 13th that was missing a region...and not the 10th with that region of 13 stuck on it which would make him balanced. It sucks that my unbalanced pregnancies are viable. Don't worry about your daughter, she's be just fine in 20yrs when it's time for her to have children.