RE says MTHFR C/A mutation needs lovenox more than homozgous C?

littlestar1 · 02-19-2009, 08:15 PM

My RE is very well respected and up to date, but possibly not on my recent homozygous MTHFR dignosis. He is out of the country until Tuesday and the nurse keeps telling me that he says an A/C mutation is more indicative of needing Lovenox than a homozygous C (two copies) mutation. This is not what I have read anywhere. Everything I have read says the CC is the worst kind for clotting and miscarriage. I am due to start stims Saturday (before the dr gets back Tuesday).

It is possible she has been relaying the information improperly, I get the impression he hasn't seen my actual labs. I am just so hesitant to start therapy without knowing what my protocol will be because if he isn't on board with Lovenox, why would I waste the cycle? I don't know enough about if we cancel what that means for future cycles. Can I quit now and still do this again in a month or do I have to start all over? Can I stay on Lupron until I get answers? My dr likes to work on a schedule where people are stimming during the first 2 weeks and ER/ET during the second 2 weeks of every month, so I would have to be on Lupron for a whole month or so. I am not comfortable being on BCP ever again with this diagnosis.

Why would my dr think this about A/C vs C/C mutation? Any information would be helpful, especially quickly due to my stim date being 2 days away.

SWOhoney · 03-24-2009, 02:02 PM

Hi, sorry no one answered this. I believe you are correct, CC mutation is the worse. My immunologist says the C gene is the bad one, the A gene doesn't really have much of an effect.

Check out Charity's MTHFR tutorial, it explains the levels of severity: http://www3.fertilethoughts.com/foru...d.php?t=610705

02-19-2009, 08:15 PM	#1 (permalink)
littlestar1 Registered User Join Date: Feb 2009 Posts: 1	RE says MTHFR C/A mutation needs lovenox more than homozgous C? My RE is very well respected and up to date, but possibly not on my recent homozygous MTHFR dignosis. He is out of the country until Tuesday and the nurse keeps telling me that he says an A/C mutation is more indicative of needing Lovenox than a homozygous C (two copies) mutation. This is not what I have read anywhere. Everything I have read says the CC is the worst kind for clotting and miscarriage. I am due to start stims Saturday (before the dr gets back Tuesday). It is possible she has been relaying the information improperly, I get the impression he hasn't seen my actual labs. I am just so hesitant to start therapy without knowing what my protocol will be because if he isn't on board with Lovenox, why would I waste the cycle? I don't know enough about if we cancel what that means for future cycles. Can I quit now and still do this again in a month or do I have to start all over? Can I stay on Lupron until I get answers? My dr likes to work on a schedule where people are stimming during the first 2 weeks and ER/ET during the second 2 weeks of every month, so I would have to be on Lupron for a whole month or so. I am not comfortable being on BCP ever again with this diagnosis. Why would my dr think this about A/C vs C/C mutation? Any information would be helpful, especially quickly due to my stim date being 2 days away.

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03-24-2009, 02:02 PM	#2 (permalink)
SWOhoney 600-699 post 8 of hearts Join Date: Oct 2008 Location: Washington, DC Posts: 608	Hi, sorry no one answered this. I believe you are correct, CC mutation is the worse. My immunologist says the C gene is the bad one, the A gene doesn't really have much of an effect. Check out Charity's MTHFR tutorial, it explains the levels of severity: http://www3.fertilethoughts.com/foru...d.php?t=610705