MTHFR C677T and elevated ANA Help!

**BC-RyansHope** · 01-02-2009, 01:21 PM

I was just dx today with MTHFR the gene mutation is C677T. The OB's NP
is going to send me a rx for folic acid and then details on which B6 and B12 vitamins to get.

Also from the same tests my ANA is significantly elevated at 2560. They want me to see a rheumatologist.
The one they recommend is booked until March. We plan on doing IVF or FET in March. I have a call into my RE to see if he can recommend someone else.

Anyone have any issues with an elevated ANA and did it have any effects on TTC?

These tests were done b/c the pathology report from the placenta showed decreased blood supply to the placenta and it was smaller than it should have been.

If anyone has any advice, I'd appreciate it.
TIA
Melissa

poohbear · 01-05-2009, 06:30 PM

Hi Melissa,
Do you know if you have one copy or two copies of the C677T mutation? If you only have one copy of the C677T mutation which about 30% of the population has most RE's don't think extra folate other than 800 mcg is necessary. I got a prescription for the Folgard or Folvee from my primary dr. for a while but I didn't like it and started taking a highly absorbable form of folate from Metagenics. I ended up seeing a rhematologist also because I had some markers that came up for lupus after immune testing through Millenova Labs but my ANA was normal. Fortunately all the other tests the rhematologist repeated and ruled out any autoimmune disease like lupus but found anti-cardiolipid antibodies which can cause clotting problems and loss in pregnancy and the tx. is lovenox. I think the tx. for the high ANA is prednisone and if you pop over on the Immune IF bb there are ladies who have experienced that. Even with the C677T mutation if you have two copies many women do lovenox before a BFP. I definitely think it is important that you are doing the testing because you want to make sure you treat any underlying issues before moving forward and because of the high ANA should definitely be explored. I understand your frustration about getting the appt. There seems to be a shortage of those type of specialists. It took me only 6 weeks to get into see the rhematologist which wasn't bad and who was very thorough but 4 months for the hematologist. Hope this helps some. HUGS
Stacey

01-02-2009, 01:21 PM	#1 (permalink)
BC-RyansHope FT Diner ~open 24/7 BYOC*~ Join Date: Oct 2006 Location: Missing my Ryan 11/6/08 Posts: 7,376 Blog Entries: 260	MTHFR C677T and elevated ANA Help! I was just dx today with MTHFR the gene mutation is C677T. The OB's NP is going to send me a rx for folic acid and then details on which B6 and B12 vitamins to get. Also from the same tests my ANA is significantly elevated at 2560. They want me to see a rheumatologist. The one they recommend is booked until March. We plan on doing IVF or FET in March. I have a call into my RE to see if he can recommend someone else. Anyone have any issues with an elevated ANA and did it have any effects on TTC? These tests were done b/c the pathology report from the placenta showed decreased blood supply to the placenta and it was smaller than it should have been. If anyone has any advice, I'd appreciate it. TIA Melissa

01-05-2009, 06:30 PM	#2 (permalink)
poohbear 5000-9999 post king of hearts Join Date: Jan 2002 Location: NYS Posts: 6,330	Hi Melissa, Do you know if you have one copy or two copies of the C677T mutation? If you only have one copy of the C677T mutation which about 30% of the population has most RE's don't think extra folate other than 800 mcg is necessary. I got a prescription for the Folgard or Folvee from my primary dr. for a while but I didn't like it and started taking a highly absorbable form of folate from Metagenics. I ended up seeing a rhematologist also because I had some markers that came up for lupus after immune testing through Millenova Labs but my ANA was normal. Fortunately all the other tests the rhematologist repeated and ruled out any autoimmune disease like lupus but found anti-cardiolipid antibodies which can cause clotting problems and loss in pregnancy and the tx. is lovenox. I think the tx. for the high ANA is prednisone and if you pop over on the Immune IF bb there are ladies who have experienced that. Even with the C677T mutation if you have two copies many women do lovenox before a BFP. I definitely think it is important that you are doing the testing because you want to make sure you treat any underlying issues before moving forward and because of the high ANA should definitely be explored. I understand your frustration about getting the appt. There seems to be a shortage of those type of specialists. It took me only 6 weeks to get into see the rhematologist which wasn't bad and who was very thorough but 4 months for the hematologist. Hope this helps some. HUGS Stacey Last edited by poohbear; 01-05-2009 at 06:36 PM.

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