Frozen embryos already affected if not treated for MTHFR during IVF cycle?

JenX · 08-27-2008, 01:39 PM

I was wondering if I have to worry about the frozen embryos we have stored...I just found out I have compound heterozygous MTHFR...is there a way to say this when speaking with docs???.....

and wonder...since I didn't take the folic acid I needed...does that mean that the embryos may already be affected by trisomy or some other genetic abnormality and should not be used....or does it only impact them once they implant???? Thanks!

atdrummin · 09-30-2008, 06:08 PM

Hi - I just found out I am hetero C for MTHFR. I had the same concerns about our frozen embryos from a previous (before I knew I had MTHFR) cycle. I asked my regular RE and another RE (see my post at http://www.websitetoolbox.com/mb/hunt123?forum=30885) and both said that the embryos are fine. They will (as any will) have a 50% chance of inheriting the MTHFR mutation, but I was told they are the same quality is if they were conceieved while on the required suppliments.

I hope that is true! If you find out anything else, please let me know.
GL-
angie

JenX · 09-30-2008, 08:02 PM

Thanks for replying...I have heard the same thing from someone on this board with MTHFR and I asked my nurse and she said the same thing...so I think we are in the clear

Good luck to you!!!

08-27-2008, 01:39 PM	#1 (permalink)
JenX 1000-4999 post queen of hearts Join Date: Nov 2006 Location: VA Posts: 3,026 Blog Entries: 12	Frozen embryos already affected if not treated for MTHFR during IVF cycle? I was wondering if I have to worry about the frozen embryos we have stored...I just found out I have compound heterozygous MTHFR...is there a way to say this when speaking with docs???..... and wonder...since I didn't take the folic acid I needed...does that mean that the embryos may already be affected by trisomy or some other genetic abnormality and should not be used....or does it only impact them once they implant???? Thanks! __________________ Jen 36 DH 39 Married 4 years IVF #1 BFN IVF#2 chemical IVF#3 civilian shared risk missed miscarriage 10w5d IVF#4 Chemical IVF#5 6/09 BFP 14dpr-233 16dpr-510 18dpr-767 different lab 21dpr-2267 Diagnosed Compound Heterozygous MTHFR and Rheumatoid Arthritis

09-30-2008, 08:02 PM	#3 (permalink)
JenX 1000-4999 post queen of hearts Join Date: Nov 2006 Location: VA Posts: 3,026 Blog Entries: 12	Thanks for replying...I have heard the same thing from someone on this board with MTHFR and I asked my nurse and she said the same thing...so I think we are in the clear Good luck to you!!! __________________ Jen 36 DH 39 Married 4 years IVF #1 BFN IVF#2 chemical IVF#3 civilian shared risk missed miscarriage 10w5d IVF#4 Chemical IVF#5 6/09 BFP 14dpr-233 16dpr-510 18dpr-767 different lab 21dpr-2267 Diagnosed Compound Heterozygous MTHFR and Rheumatoid Arthritis

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09-30-2008, 06:08 PM	#2 (permalink)
atdrummin Registered User Join Date: Nov 2007 Location: Long Beach, CA Posts: 15	Hi - I just found out I am hetero C for MTHFR. I had the same concerns about our frozen embryos from a previous (before I knew I had MTHFR) cycle. I asked my regular RE and another RE (see my post at http://www.websitetoolbox.com/mb/hunt123?forum=30885) and both said that the embryos are fine. They will (as any will) have a 50% chance of inheriting the MTHFR mutation, but I was told they are the same quality is if they were conceieved while on the required suppliments. I hope that is true! If you find out anything else, please let me know. GL- angie