Slow rising betas (of course)

[rashin4]

thanks for positive words TTC! v scared and praying hard!

[rashin4]

my beta has been
starting 10 dp5dt every 48 hrs- 15,15,29, 95, 190
and then ;(((
72 hrs later today- 367 not even doubled after 72 hours!... any hope... U/S on thu or fri

[SC-emk808]

I responded on your other post... Good luck!

[rashin4]

Hi Ladies,

I just found out today that on 6w1d U/S that I am miscarrying after 1st ivf . It didn't came as a surprise as my beta started low, even though it kept rising. I am still heartbroken as I was expecting a miracle and hope got enlightened every time beta doubled although it was very low.

now I have a couple of day 5 and day 6 embryos, with mixed grades of AB and BC. I have mild PCOS, no insulin resistance, all labs pcos relted and day 3 normal, TSH <2, PCO ovaries- long irregular cycles generally ovulation happens between day 11-23; sometimes anovulatory.

based on this please let me know what you think of these things?
1. RE thinks dnc is not required as m/c is too early. also didn't see much tissue in U/S to analyse for cause of failure.. any thoughts

2. RE is not hesitant to do a FET right after m/c? Is it ok.. has anyone had success with FET right after IVF resulting in CP or miscarriage? i know some clinics wait 3 months..

3. he transferred 2, and thinks we should transfer 3 next time? is it feasible considering I am 30 and did have implantation last cycle.

4. biggest thing- Should I do a NATURAL or MEDICATED- considering my history. Although I prefer natural but is it difficult to find implantation window exactly in natural FET? anyone had success with NATURAL FET? I will definitely do medicated if it has favorable results

[SC-emk808]

I am so, so sorry rashin. I'll try to answer some of your questions to the best of my ability to help you through this rough time.

1) I personally don't like doing d/c unless it's 100% necessary (ie missed miscarriage or need to test for abnormality because it's your 3rd miscarriage or more). If you start bleeding on your own, then I wouldn't bother quite yet. It's not a fun procedure and can cause more trauma than good sometimes. Many women miscarry once and then go on to have healthy pregnancies (myself included). The majority of the time it's because of a chromosomal abnormality that's not likely to repeat a second time. If you miscarry three times in a row, then it's time to get the tissue tested (on the 3rd one). But that is actually quite rare.

2) There's no reason to wait, especially with an early miscarriage. Many women are *more* fertile following a miscarriage, and I feel that you are more likely to have a successful pregnancy. As long as your hCG returns to normal quickly, then you are all set to try again. The only reason to wait is if you are having a late m/c or your hCG is slow to return to zero.

3) That's your choice, really. I wouldn't transfer any more embryos than you're willing to carry to term. If you think you could handle carrying triplets if you had a miracle, then transfer three. If the thought of triplets scares you to pieces, then I would stick to two. 30 is not old! You have very slightly lower fertility than someone doing a cycle who's 25. So honestly, I would do two. If you were 35 then I would say maybe to go to three. The fact that you had implantation this cycle makes me even less likely to choose three embryos because it means something's working.

4) This is also really up to you. I know absolutely nothing about natural vs medicated FET. I would ask your doc what he recommends.

Good luck!!!!

[rashin4]

Thanks BC-emk808

Thanks a lot for your accurate and quick reply.

Makes me feel better about not doing a D and C but would have been good if I would have bene able to find out if embryo was chromosomally abnormal since we have significant male factor

I also personally don't want to wait, however I am contemplating if I should do a natural FET which could be difficult since I don't ovulate on time. Sometimes they say they miss the window of implantation exactly in a natural cycle... so have to research more on this the FET board..

I also think considering it implanted I will prefer to transfer two day 5 only for atleast the next FET. If god forbid that fails then I might transfer all three on the subsequent FET because then remaining ones will be all day 6 and poorer quality than day 5.

[SC-emk808]

If you don't ovulate on time, then I would recommend a medicated FET. I've heard that it can be more difficult to become (and stay) pregnant if you ovulate after day 16 of your cycle. So you might boost your chances of success by forcing ovulation to take place on time. It also would be easier to pinpoint exactly when you should be doing the FET.

I think that's a good idea (to do 2 embryo transfer for the next try and then if it doesn't work to go with 3). But see if they are able to do PGD first to make sure that you are transferring quality embryos. There's no point in transferring embryos that are chromosomally abnormal... I have my fingers crossed for a quick conception and full term pregnancy!

[TTCyears]

So sorry. Wishing you a speedy recovery.

1. I naturally mc'd all my pg losses prior to 7w and would do so again. Losses prior to 6w were like heavy AF and losses past 6w were intense but doable.

2. I waited 3 mos once, but never again. I've seen many of my IVF friends jump right back in the next cycle after an early loss, seems pretty typical.

3. I would only transfer 1-2 at your age unless the dr expects an unusually high amount of abnormal embies, e.g. due to MF.

4. I tried a natural FET but I'm a late O'er and my lining was mismatched and blood flow weird so it was cancelled. I did the Estrogen suppression the next cycle and that was fine.

I did genetic testing. My Day 5 blasts with excellent grades, e.g. 5AA, were Abnormal (with multiple fatal genetic errors). My Day 6 blasts with mediocre grades, e.g. 4BB, were Normal. REPEAT: My "worst" embryos were actually my best chance to bear a child. If I had transferred my "best" Day 5 blasts, I would have had a BFN or mc (and cried my eyes out thinking I had transferred the best and had nothing and what was wrong with my body --- when it was just chance!!!!!!!!). Instead I transferred one Day 6 mediocre embryo and got my sticky BFP. I obviously absolutely believe that Day 6 can be better quality than Day 5. I've seen this happen to enough other couples to know it's not personal, it just happens that way sometimes.

Wishing you truly best are soon to come!

[rashin4]

Ttc years - Its amazing to have still been trying after so many losses. I applaud you for your determination.

1.Did your friends gets success when they jumped on to FET or fresh cycle very next cycle?
2. We have significant MFI, and grade 4AAA and 3AAA were transferred this time leading to m/c. Maybe that;s why he is talking abt 3.
3.We have a total of 5 frozen

2 on Day 5- full blastocyst 3AAA and 3BCC
3 on day 6- expanded blastocyst 4BBB and 2 full blastocysts at 3BBB.

we did ask about PGD, and he says we could do it for FET';s but the problem is if we get more than 3 normal embies,, lets say 4 or all 5, it will be hard to refreeze the others which won't be transferred and they would probably not survive thaw later. He suggested if worst case scenario we do come to a point that we have to do a Fresh IVF cycle #2, then it makes sense doing PGD on all embies.

[TTCyears]

Thanks. It was tough to say the least.

Yes, most my IVF friends eventually had success jumping right into next FET cycles.

Wow, they grade yours on four categories. Fancy (wink).

It's weird because I hadn't heard much about Day 6 over the years but now I do a lot. Day 5 and Day 6 3's and 4's definitely make babies! (and I've heard of Day 6 2's also - I have one.) My fingers are crossed that you have 2 or so babes in your 5 snowbabies ... awaiting their chance... soon...