2nd beta is in

[Amyelynn]

Went from 105 to 171 in two days....doubling time of 68 hours....

I'm a bit concerned.......

any experience or words of wisdom?

OH and I've been have some what seems like EWCM, anyone else?

[stephngregg]

In early pregnancy it's completely normal for HCG levels to double every 48-72 hours.

What Do the Numbers Mean?
The problem is, once a pregnancy is confirmed, you need to know if it progressing along normally. Keeping track of HCG numbers is one way of measuring fetal viability. HCG is measured in milli-international units per millimeter (mIU/ml). HCG is first detectable in the blood as early as seven or eight days after ovulation by very sensitive HCG assays. Blood pregnancy tests will be positive (> 2 mIU/ml) by 10 or 11 days after HCG injection or LH surge, and levels vary with gestational age during pregnancy.

There is a large variation in a "normal" HCG level for any given time in pregnancy. Caution must be used in making too much of HCG "numbers." Ultrasound findings after five or six weeks of pregnancy are much more predictive of pregnancy outcome than are HCG levels. You won't expect to see a gestational sac or the fetus until the HCG level reaches at least 1,200 mIU/ml.

However, a single HCG level cannot indicate a normal pregnancy. In a normal pregnancy there is a regular increase of the HCG, so you need to see more than one value before you can better understand what's going on. Additionally, a single value cannot always tell you how far along the pregnancy is, because of the wide range of blood HCG levels in pregnancy. To illustrate the limitations of looking at a single measurement, here is a sample reference list for HCG levels in singleton pregnancies, based on days past ovulation (DPO):

* At 14 DPO, the average HCG level is 48 mIU/ml, with a typical range of 17-119 mIU/ml.
* At 15 DPO, the average HCG level is 59 mIU/ml, with a typical range of 17-147 mIU/ml.
* At 16 DPO, the average HCG level is 95 mIU/ml, with a typical range of 33-223 mIU/ml.
* At 17 DPO, the average HCG level is 132 mIU/ml, with a typical range of 17-429 mIU/ml.
* At 18 DPO, the average HCG level is 292 mIU/ml, with a typical range of 70-758 mIU/ml.
* At 19 DPO, the average HCG level is 303 mIU/ml, with a typical range of 111-514 mIU/ml.
* At 20 DPO, the average HCG level is 522 mIU/ml, with a typical range of 135-1690 mIU/ml.
* At 21 DPO, the average HCG level is 1061 mIU/ml, with a typical range of 324-4130 mIU/ml.
* At 22 DPO, the average HCG level is 1287 mIU/ml, with a typical range of 185-3279 mIU/ml.
* At 23 DPO, the average HCG level is 2034 mIU/ml, with a typical range of 506-4660 mIU/ml.
* At 24 DPO, the average HCG level is 2637 mIU/ml, with a typical range of 540-10,000 mIU/ml.

Accordingly, the key to interpreting the true value of HCG measurements is to look at their progression. In general, the HCG level will double every two to three days in early pregnancy. Approximately 85 percent of normal pregnancies will have the HCG level double every 72 hours. However, as you get further along in your pregnancy and the HCG levels get higher, the expected doubling time increases.

* For HCG levels <1200 mIU/ml, the expected doubling time is 48-72 hours.
* For HCG levels 1200 to 6000 mIU/ml, the expected doubling time is 72-96 hours.
* For HCG levels >6000 mIU/ml, the expected doubling time is >96 hours.

HCG levels peak at about eight to 10 weeks of pregnancy and then decline, remaining at lower levels for the rest of the pregnancy. Here is a sample listing of expected HCG levels based on time after conception:

* 0-1 week: 0-50 mIU/ml
* 1-2 weeks: 40-300 mIU/ml
* 3-4 weeks: 500-6,000 mIU/ml
* 1-2 months: 5,000-200,000 mIU/ml
* 2-3 months: 10,000-100,000 mIU/ml
* 2nd trimester: 3,000-50,000 mIU/ml
* 3rd trimester: 1,000-50,000 mIU/ml
* Non-pregnant females: <5.0 mIU/ml
* Postmenopausal females: <9.5 mIU/ml

[Libra102]

Beta #1 9dpt5dt - 100
Beta #2 11dpt5dt - 181 doubled in 56 hours
Beta #3 15dpt5dt - 577 doubled in 57 hours
Beta #4 18dpt5dt - 1835 doubled in 43 hours
Beta #5 22dpt5dt - 6529 doubled in 52 hours

Never did my RE or the nurses seemed concerned about the doubling time. As long as it doubles in 72 hours you are fine. I am 9 weeks 3 days and have seen my little bean 3 times via u/s and according to the RE and OB everything looks fine. Numbers are just that...numbers. Every one is different, 48 hours is just an approximation.

It is easier said then done but speaking through experience please don't worry. As long as you don't have any cramping, spotting and your betas double every 3 days you are fine.

Congratulations and enjoy.

Big hugs
Erika

[Siszi]

1st 30
2nd 74
3rd 134

They told me I'm pregnant, but I have seen a lot high numbers. I'm don't want to be worried no more but now it's in my head and until I hear the heart bit I will really believe it.