Beta numbers/rising fast

EmberLS · 06-30-2005, 07:25 PM

My beta numbers more than quadrupled in 48 hrs.
13dpiui - 185
15dpiui - 767

Is this something I should be concerned with? What is a molar pregnancy? Any input would be greatly appreciated. Thanks.

Christinella · 07-01-2005, 01:07 PM

I got this off the internet - I hope this is not what you have. Why would you think that?

A molar pregnancy happens when you have an abnormality in the fertilized egg at conception. The fertilized egg either never develops into an embryo (this is called a complete mole) or it develops abnormally and can't survive (this is a partial mole). In normal pregnancies, the fertilized egg contains 23 chromosomes from the father and 23 from the mother. In most complete molar pregnancies, the fertilized egg contributes no maternal chromosomes and the chromosomes from the father's sperm are duplicated, so you end up with two copies of chromosomes from the father and none from the mother. In this case, there's no embryo, amniotic sac, or any normal placental tissue. Instead, the placenta forms a mass of cysts.

In most partial molar pregnancies, the fertilized egg has the normal complement of chromosomes from the mother but double the chromosomes from the father, so there are 69 chromosomes instead of the normal 46. (This can happen when chromosomes from the sperm are duplicated or when two sperm fertilize the same egg.) In this case, there's some normal placental tissue among the cluster-like mass of abnormal tissue. The embryo does begin to develop, so there may be a fetus (or just some fetal tissue or an amniotic sac), but even if a fetus is present, it's so abnormal that it can't survive except in very rare cases.

TRC · 07-01-2005, 01:49 PM

I guess my first questions is did you do IVF, IUI, etc.? How many embryos did you tf or how many follies did you have? These #'s look like a possible multiple pg.

janetm · 07-05-2005, 07:41 AM

I agree with Theresa. I think multiples are a lot more likely than a molar pg. Then again you just never know. There are plenty of women with quick rising betas with healthy singletons. Between my first and second betas I was doubling every 30 hours and was freaked out about multiples. However its just a singleton. Bottom line is until you have an ultrasound you won't really know.

-janetm

EmberLS · 07-05-2005, 11:52 AM

Thanks so much for the advice. I think it was just initial shock. The doctor says he is not the least bit concerned about eptopic or anything else. I am having a sonogram on Thurs. So I guess I will know then if it is a singleton or mult.
TRC - I had an 2 IUI's 24 hrs apart. I had one follicle at 23 and one at 18 when I triggered. So I guess there is a possibility the second caught up.

I have just decided to stay positive. I guess when you try so hard to conceive you just really worry about something going wrong. Thanks so much for all the posts.

tsimpson · 07-14-2005, 05:25 PM

I am preg w/ 2nd child. Daughter is 10 years old. I am only 5 weeks and am into maternity clothes. My beta at 20 dpo was 98 and at 22 dpo was 426. I have read that a doubling time of 22 hours could mean multiples. I have an ultrasound on 7/25 (11 more days, forever, I am going nuts). I did not show until 5 months last time. Husband and myself have no twins in famillies. And this is natural, no IVF or other. What do you guys think?

Christinella · 07-15-2005, 03:59 AM

tsimpson,

I posted to you on the other thread. Congrats on the pg!!!! Your numbers seem in line with a single pg - although beta numbers are not always a good indication.

Mine were (single pg)

15 dpo - 235
18 dpo - 698
25 dpo - 10,468

Go to www. betabase.info and you can see where you numbers fall on averages.

Good luck with the u/s!

Christie

Monica2 · 07-15-2005, 01:28 PM

Hi -- That doesn't look like such a shocking jump. There is a huge range of beta numbers and they are supposed to double every 48-72 -- that doesn't mean it's bad if they go up faster.

Plus you know, no one does all these millions of betas on non-IF patients, for all we know those numbers are the norm in the fertile population. Congrats and good luck!

3XMAMAWANNABE · 07-15-2005, 04:24 PM

Hey there! Congrats on your pregnancy. Your beta is definitely increasing quickly, but from what I have heard about molars, it is more extreme... like quickly jumping into the 10,000-50,000's, although I am certainly no authority on this one.

I do know that more than doubling in 48 hours is supposed to be a possible indicator of multiples, but mine did not double in 48 hrs with my current pregnancy and it is seemingly healthy triplets. My RE says that betas are fairly unreliable and that the important thing is that it does not sky rocket (which I don't think yours have) or increase by less than 60% every 48 hours.

Good luck and congrats again!

Isabella

tsimpson · 07-15-2005, 06:50 PM

Thank you guys so much. I feel much better now. I will post after my u/s.

06-30-2005, 07:25 PM	#1 (permalink)
EmberLS Registered User Join Date: May 2005 Location: Texas Posts: 13	Beta numbers/rising fast My beta numbers more than quadrupled in 48 hrs. 13dpiui - 185 15dpiui - 767 Is this something I should be concerned with? What is a molar pregnancy? Any input would be greatly appreciated. Thanks.

07-01-2005, 01:49 PM	#3 (permalink)
TRC Registered User Join Date: Dec 2002 Location: Yakima, WA Posts: 1,342	I guess my first questions is did you do IVF, IUI, etc.? How many embryos did you tf or how many follies did you have? These #'s look like a possible multiple pg. __________________ Theresa 42 / Dh 34 IVF#1 - 12/01 cancelled DFET#1 - 12/02 (3,4,7 cell & 1 blast)BFN Diff. DFET#2 - tf 10/22 (two 8 & two 10 cell) BFP 1st beta 12dpt 499 / 2nd beta 14dpt 1392.93 Noah, Ian, & Garrett born 4/30/04 @ 29.5d - I'm a mommy at last!

07-15-2005, 01:28 PM	#8 (permalink)
Monica2 1000-4999 post queen of hearts Join Date: Jan 2002 Posts: 2,606	Hi -- That doesn't look like such a shocking jump. There is a huge range of beta numbers and they are supposed to double every 48-72 -- that doesn't mean it's bad if they go up faster. Plus you know, no one does all these millions of betas on non-IF patients, for all we know those numbers are the norm in the fertile population. Congrats and good luck! __________________ Monica TTC #1 3/98 - 12/02; 4 early losses IVF #2 -- DD "L" b. 12/22/02 after 16 wks of bed rest TTC #2 starting 4/04; 4 failed FETs IVF #3 -- B/G twins "J" & "S" b. 3/1/06

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07-01-2005, 01:07 PM	#2 (permalink)
Christinella Registered User Join Date: Apr 2005 Posts: 207	I got this off the internet - I hope this is not what you have. Why would you think that? A molar pregnancy happens when you have an abnormality in the fertilized egg at conception. The fertilized egg either never develops into an embryo (this is called a complete mole) or it develops abnormally and can't survive (this is a partial mole). In normal pregnancies, the fertilized egg contains 23 chromosomes from the father and 23 from the mother. In most complete molar pregnancies, the fertilized egg contributes no maternal chromosomes and the chromosomes from the father's sperm are duplicated, so you end up with two copies of chromosomes from the father and none from the mother. In this case, there's no embryo, amniotic sac, or any normal placental tissue. Instead, the placenta forms a mass of cysts. In most partial molar pregnancies, the fertilized egg has the normal complement of chromosomes from the mother but double the chromosomes from the father, so there are 69 chromosomes instead of the normal 46. (This can happen when chromosomes from the sperm are duplicated or when two sperm fertilize the same egg.) In this case, there's some normal placental tissue among the cluster-like mass of abnormal tissue. The embryo does begin to develop, so there may be a fetus (or just some fetal tissue or an amniotic sac), but even if a fetus is present, it's so abnormal that it can't survive except in very rare cases.

07-05-2005, 07:41 AM	#4 (permalink)
janetm Registered User Join Date: Nov 2004 Posts: 72	I agree with Theresa. I think multiples are a lot more likely than a molar pg. Then again you just never know. There are plenty of women with quick rising betas with healthy singletons. Between my first and second betas I was doubling every 30 hours and was freaked out about multiples. However its just a singleton. Bottom line is until you have an ultrasound you won't really know. -janetm

07-05-2005, 11:52 AM	#5 (permalink)
EmberLS Registered User Join Date: May 2005 Location: Texas Posts: 13	Thanks so much for the advice. I think it was just initial shock. The doctor says he is not the least bit concerned about eptopic or anything else. I am having a sonogram on Thurs. So I guess I will know then if it is a singleton or mult. TRC - I had an 2 IUI's 24 hrs apart. I had one follicle at 23 and one at 18 when I triggered. So I guess there is a possibility the second caught up. I have just decided to stay positive. I guess when you try so hard to conceive you just really worry about something going wrong. Thanks so much for all the posts.

07-14-2005, 05:25 PM	#6 (permalink)
tsimpson Registered User Join Date: Jul 2005 Location: South Carolina Posts: 5	I am preg w/ 2nd child. Daughter is 10 years old. I am only 5 weeks and am into maternity clothes. My beta at 20 dpo was 98 and at 22 dpo was 426. I have read that a doubling time of 22 hours could mean multiples. I have an ultrasound on 7/25 (11 more days, forever, I am going nuts). I did not show until 5 months last time. Husband and myself have no twins in famillies. And this is natural, no IVF or other. What do you guys think?

07-15-2005, 03:59 AM	#7 (permalink)
Christinella Registered User Join Date: Apr 2005 Posts: 207	tsimpson, I posted to you on the other thread. Congrats on the pg!!!! Your numbers seem in line with a single pg - although beta numbers are not always a good indication. Mine were (single pg) 15 dpo - 235 18 dpo - 698 25 dpo - 10,468 Go to www. betabase.info and you can see where you numbers fall on averages. Good luck with the u/s! Christie

07-15-2005, 04:24 PM	#9 (permalink)
3XMAMAWANNABE Registered User Join Date: Jun 2005 Location: Indiana Posts: 626	Hey there! Congrats on your pregnancy. Your beta is definitely increasing quickly, but from what I have heard about molars, it is more extreme... like quickly jumping into the 10,000-50,000's, although I am certainly no authority on this one. I do know that more than doubling in 48 hours is supposed to be a possible indicator of multiples, but mine did not double in 48 hrs with my current pregnancy and it is seemingly healthy triplets. My RE says that betas are fairly unreliable and that the important thing is that it does not sky rocket (which I don't think yours have) or increase by less than 60% every 48 hours. Good luck and congrats again! Isabella

07-15-2005, 06:50 PM	#10 (permalink)
tsimpson Registered User Join Date: Jul 2005 Location: South Carolina Posts: 5	Thank you guys so much. I feel much better now. I will post after my u/s.