baby asprin?

[triciaism]

Not sure this is the right place to post but . . .
Is baby asprin ok while trying to conceive. My signature tells my story but have heard many say it helped them. I've been taking it since I started the injections this time but have been thinking maybe I should wait till after the iui? Not sure if it will hurt or maybe help w/implantation when the time comes.
Any advice welcome!
Thanks,
Tricia

[BC-Maura]

Hi Tricia: I have seen women here take baby aspirin to help with implantation or after recurrent m/cs. I just looked around internet to find more and found this:

"Aspirin
Low-dose aspirin (80mg or 1 baby aspirin) alone has used for treatment of both repeat implantation failures and post-implantation pregnancy losses. Aspirin therapy has been reported to enhance implantation rates in women undergoing IVF/ET. In these studies the number of eggs retrieved and number of embryos generated were higher in the aspirin treated group than in the non-treated group making it unclear whether the enhancement in implantation rate was the result of better embryo selection or a direct effect on the lining of the uterus. Among women with increased resistance of blood flow through their uterine arteries who were treated with aspirin for a minimum of two weeks, the pregnancy rate was increased from 17% to 47% and the miscarriage rate decreased from 60% to 15%. As a prostaglandin inhibitor, aspirin would be expected to increase blood flow to the ovary prior to implantation, to the endometrium during implantation and to prevent clotting of the placental vessels following implantation. However, in studies of women experiencing recurrent post-implantation pregnancy loss/miscarriage associated with antiphospholipid antibodies, results of clinical trials have shown aspirin alone to be half as effective as other treatments including heparin and steroids. In two studies women receiving aspirin alone or heparin plus aspirin for treatment of repeat pregnancy loss associated with antiphospholipid antibodies, heparin plus aspirin provided a significantly better outcome that aspirin alone (live birth rate of 80% vs 44%).
A rationale for the use of low-dose aspirin therapy during pregnancy for women with antiphospholipid antibodies is to decrease blood clots from forming in the placental vessels. The mechanisms by which aspirin prevents blood clots are through its antiprostaglandin and antiprostacyclin effects and inhibition of platelet adhesiveness and aggregation."

It's from the i*n*c*i*i*d site (sorry, the software here won't allow me to type it out normally ).

I wouldn't take aspirin unless you've consulted with your doctor and been advised to do so.

Best of luck with your IUI and let us know how you make out!

+++++++++++++
Maura

[hoden]

Hi Tricia,

I was on low-dose asprin for while doing IVF and thankfully all the way through my pregnancy. Nothing to worry about!

[caliMD]

Aspirin does not only inhibits prostaglandins but also is an anticoagulant of sorts. It inhibits platelet function. In those women whose miscarriages are due to an undiagnosed hypercoaguable state, such as antiphospholipid antibody syndromes, aspirin might be beneficial in maintaining a pregnancy.

[Gemma]

Tricia - I'm on asprin from the start of tx. No problem with taking it provided it's under medical supervision hon. xx

[triciaism]

Thanks ladies for all your feedback.

My doctor did not give me a straight answer, they don't do IVF but he said "they do it for IVF", but after some "perfect" cycles - I thought that baby asprin might not hurt. I've had one m/c and possible implantation issues since the last two cycles were supposed to be so "perfect". Figured I'm being monitored through my cycle so I might as well try it.

Thanks again for your feedback!!!